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2(1H)-Pyrazinone, 3-phenyl-, also known as 2-Hydroxy-3-phenylpyrazine, is a degradation product of Cefaclor (C235250), a second-generation cephalosporin antibiotic. It is a chemical compound with the molecular formula C9H8N2O and a molecular weight of 152.17 g/mol. The structure of 2(1H)-Pyrazinone, 3-phenylconsists of a pyrazine ring with a phenyl group attached to the 3-position and a hydroxyl group at the 2-position.

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  • 2882-18-0 Structure
  • Basic information

    1. Product Name: 2(1H)-Pyrazinone, 3-phenyl-
    2. Synonyms: 2(1H)-Pyrazinone, 3-phenyl-;2-hydroxy-3-phenylpyrazine;3-Phenyl-1H-pyrazin-2-one;3-Phenyl-2(1H)-pyrazinone;3-Phenylpyrazin-2(1H)-one;Cefaclor EP Impurity F
    3. CAS NO:2882-18-0
    4. Molecular Formula: C10H8N2O
    5. Molecular Weight: 172.18
    6. EINECS: N/A
    7. Product Categories: Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
    8. Mol File: 2882-18-0.mol
  • Chemical Properties

    1. Melting Point: 172-174℃
    2. Boiling Point: 457.4 °C at 760 mmHg
    3. Flash Point: 230.5 °C
    4. Appearance: /
    5. Density: 1.20
    6. Vapor Pressure: 5.48E-09mmHg at 25°C
    7. Refractive Index: 1.623
    8. Storage Temp.: Refrigerator
    9. Solubility: Chloroform (Slightly), Methanol (Slightly)
    10. PKA: 11.26±0.40(Predicted)
    11. CAS DataBase Reference: 2(1H)-Pyrazinone, 3-phenyl-(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2(1H)-Pyrazinone, 3-phenyl-(2882-18-0)
    13. EPA Substance Registry System: 2(1H)-Pyrazinone, 3-phenyl-(2882-18-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2882-18-0(Hazardous Substances Data)

2882-18-0 Usage

Uses

Used in Pharmaceutical Industry:
2(1H)-Pyrazinone, 3-phenylis used as a degradation product of Cefaclor, a second-generation cephalosporin antibiotic. It is important to monitor and control the presence of this impurity in the manufacturing process of Cefaclor to ensure the quality, safety, and efficacy of the final product. The study of degradation products like 2(1H)-Pyrazinone, 3-phenylalso helps in understanding the stability and shelf life of pharmaceutical compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 2882-18-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,8 and 2 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2882-18:
(6*2)+(5*8)+(4*8)+(3*2)+(2*1)+(1*8)=100
100 % 10 = 0
So 2882-18-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H8N2O/c13-10-9(11-6-7-12-10)8-4-2-1-3-5-8/h1-7H,(H,12,13)

2882-18-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Phenyl-2(1H)-pyrazinone

1.2 Other means of identification

Product number -
Other names 3-Phenyl-2-hydroxy-pyrazin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2882-18-0 SDS

2882-18-0Relevant articles and documents

Isolation and identification of a fluorophore from ampicillin degradation

Lebelle,Vilim,Wilson

, p. 441 - 443 (1979)

A fluorescent impurity in ampicillin has been isolated and identified as 2-hydroxy-3-phenyl-pyrazine. The product is formed under acidic conditions similar to those employed in some fluorometric assay procedures. The mechanism of the reaction is proposed to involve cyclization by condensation of the penilloaldehyde of ampicillin. The structure was confirmed by independent synthesis.

SIGMA-1 RECEPTOR LIGANDS AND THERAPEUTIC USES THEREOF

-

, (2021/06/26)

The present invention relates to the field of medicine. More specifically, the present invention relates to compounds that are sigma-1 receptor agonists and their use for the treatment of central nervous system disorders, including cognitive or neurodegen

Electrochemical Cross-Coupling of C(sp2)?H with Aryldiazonium Salts via a Paired Electrolysis: an Alternative to Visible Light Photoredox-Based Approach

Jiang, Yang-ye,Dou, Gui-yuan,Zhang, Luo-sha,Xu, Kun,Little, R. Daniel,Zeng, Cheng-chu

, p. 5170 - 5175 (2019/11/13)

Photoredox-based C?H bond functionalization constitutes one of the most powerful and atom-economical approaches to organic syntheses. During this type of reaction, single electron transfer takes place between the photocatalyst (PC) and redox- active substrates. Electrosynthesis also involves electron transfer between substrates and electrodes. In this paper, we focus upon electrochemical cross-coupling of C(sp2)?H with aryldiazonium salts and have developed an efficient electrochemical approach to the Minisci-type arylation reaction. The constant current paired electrosynthesis proceeds in a simple undivided cell without external supporting electrolyte, features a wide range of substrates and is easy to scale-up. These results demonstrate that photoredox-based cross-coupling of C(sp2)?H with aryldiazonium salts can also proceed successfully under paired electrolysis conditions, thereby contributing to understanding of the parallels between photosynthesis and electrosynthesis. (Figure presented.).

ALPHA-4 INTEGRIN MEDIATED CELL ADHESION INHIBITORS FOR THE TREATMENT OR PREVENTION OF INFLAMMATORY DISEASES

-

Page/Page column 32, (2010/02/13)

The present invention relates to novel compounds of formula (I), processes for their preparation, compositions comprising them and their use in the treatment or prevention of diseases capable of being modulated by the inhibition of cell adhesion.

Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: Preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods

Semple, Graeme,Andersson, Britt-Marie,Chhajlani, Vijay,Georgsson, Jennie,Johansson, Magnus J.,Rosenquist, Asa,Swanson, Lars

, p. 1141 - 1145 (2007/10/03)

New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution- and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald reactions. Opioid receptor binding data for the compounds produced is reported.

Isolation and structure elucidation of a novel product of the acidic degradation of cefaclor

Baertschi,Dorman,Occolowitz,Spangle,Collins,Wildfeuer,Lorenz

, p. 622 - 626 (2007/10/02)

The acidic aqueous degradation of cefaclor, an orally administered cephalosporin antibiotic, has been investigated. The most prominent peak in the high-performance liquid chromatography profile of a degraded solution of cefaclor was isolated by preparative high-performance liquid chromatography. Mechanistically, the formation of this degradent from cefaclor involves a condensation of two cefaclor degradation products in which both products have undergone contraction from a six-membered cephem ring to a five-membered thiazole ring, presumably via a common episulfonium ion intermediate.

Novel (substituted phenyl)-1,2,4-triazolo (4,3-A)pyrazines and novel 2-hydrazino-(substituted phenyl)pyrazine intermediates

-

, (2008/06/13)

This disclosure describes novel 5-,6- and 8-(phenyl and substituted phenyl)-1,2,4-triazolo[4,3-a]pyrazines which posses utility as anxiolytic agents.

Some Reactions of Mono Substituted Pyrazine Monoxides

Ohta, Akihiro,Watanabe, Tokuhiro,Akita, Yasuo,Yoshida, Maki,Toda, Suzumi,et al.

, p. 1061 - 1067 (2007/10/02)

The reactions of the monoxides of propylpyrazine and phenylpyrazine with phosphoryl chloride or acetic anhydride were investigated.Except in the case of the reaction of 2-propylpyrazine 1-oxide with acetic anhydride, chlorination or acetoxylation occurred

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