2882-18-0

Basic information

• Product Name: 2(1H)-Pyrazinone, 3-phenyl-
• Synonyms: 2(1H)-Pyrazinone, 3-phenyl-;2-hydroxy-3-phenylpyrazine;3-Phenyl-1H-pyrazin-2-one;3-Phenyl-2(1H)-pyrazinone;3-Phenylpyrazin-2(1H)-one;Cefaclor EP Impurity F
• CAS NO: 2882-18-0
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.18
• Product Categories: Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 2882-18-0.mol

Chemical Properties

• Melting Point: 172-174℃
• Boiling Point: 457.4 °C at 760 mmHg
• Flash Point: 230.5 °C
• Appearance: /
• Density: 1.20
• Vapor Pressure: 5.48E-09mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 11.26±0.40(Predicted)
• CAS DataBase Reference: 2(1H)-Pyrazinone, 3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrazinone, 3-phenyl-(2882-18-0)
• EPA Substance Registry System: 2(1H)-Pyrazinone, 3-phenyl-(2882-18-0)

Safety Data

• Hazardous Substances Data: 2882-18-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2(1H)-Pyrazinone, 3-phenylis used as a degradation product of Cefaclor, a second-generation cephalosporin antibiotic. It is important to monitor and control the presence of this impurity in the manufacturing process of Cefaclor to ensure the quality, safety, and efficacy of the final product. The study of degradation products like 2(1H)-Pyrazinone, 3-phenylalso helps in understanding the stability and shelf life of pharmaceutical compounds.

InChI:InChI=1/C10H8N2O/c13-10-9(11-6-7-12-10)8-4-2-1-3-5-8/h1-7H,(H,12,13)

Upstream product

• 6270-63-9 pyrazin-2(1H)-one 
• 100-34-5 benzene diazonium chloride 
• 64753-81-7 cefaclor 
• 160315-09-3 2-acetoxy-3-phenylpyrazine 
• 58861-89-5 2-phenylpyrazine N⁽¹⁾-oxide 
• 58861-94-2 2-phenylpyrazine 4-oxide 
• 98-80-6 phenylboronic acid 
• 41270-65-9 2-chloro-3-phenylpyrazine 
• 58861-87-3 2-chloro-3-phenyl-pyrazine 4-oxide 
• 29460-97-7 2-phenylpyrazine 
• 1074-12-0 phenylglyoxal hydrate 
• 40966-78-7 2-(R)-2-phenyl-2-aminoacetyl chloride hydrochloride 
• 131543-46-9 Glyoxal 
• 700-63-0 Phenylglycinamid 

Downstream Products

• 2882-16-8 3-phenylpyrazine-2-carbonitrile 
• 99984-63-1 2-methoxy-3-phenylpyrazine 
• 64163-09-3 2,5-dichloro-6-phenylpyrazine 
• 64163-10-6 3,6-dibromo-5-phenylpyrazine 
• 64163-16-2 5-chloro-6-phenyl-1H-pyrazin-2-one 
• 102653-50-9 5-chloro-3-phenyl-2(1H)-pyrazinone 
• 104092-52-6 5-chloro-2-methoxy-3-phenyl-pyrazine 
• 860410-57-7 2-chloro-5-methoxy-3-phenylpyrazine 
• 99984-69-7 3-methoxy-2-phenyl-pyrazine-1-oxide 
• 100142-71-0 2,5-dimethoxy-3-phenyl-pyrazine 
• 98948-89-1 3-bromo-5-chloro-6-phenyl-1H-pyrazin-2-one 
• 74134-66-0 5-chloro-3,6-diphenyl-1H-pyrazin-2-one 
• 41270-65-9 2-chloro-3-phenylpyrazine 
• 243472-81-3 2-phenyl-3-trimethylsilanyloxy-pyrazine 

Relevant articles and documents

Isolation and identification of a fluorophore from ampicillin degradation

A fluorescent impurity in ampicillin has been isolated and identified as 2-hydroxy-3-phenyl-pyrazine. The product is formed under acidic conditions similar to those employed in some fluorometric assay procedures. The mechanism of the reaction is proposed to involve cyclization by condensation of the penilloaldehyde of ampicillin. The structure was confirmed by independent synthesis.

SIGMA-1 RECEPTOR LIGANDS AND THERAPEUTIC USES THEREOF

The present invention relates to the field of medicine. More specifically, the present invention relates to compounds that are sigma-1 receptor agonists and their use for the treatment of central nervous system disorders, including cognitive or neurodegen

Electrochemical Cross-Coupling of C(sp2)?H with Aryldiazonium Salts via a Paired Electrolysis: an Alternative to Visible Light Photoredox-Based Approach

Photoredox-based C?H bond functionalization constitutes one of the most powerful and atom-economical approaches to organic syntheses. During this type of reaction, single electron transfer takes place between the photocatalyst (PC) and redox- active substrates. Electrosynthesis also involves electron transfer between substrates and electrodes. In this paper, we focus upon electrochemical cross-coupling of C(sp2)?H with aryldiazonium salts and have developed an efficient electrochemical approach to the Minisci-type arylation reaction. The constant current paired electrosynthesis proceeds in a simple undivided cell without external supporting electrolyte, features a wide range of substrates and is easy to scale-up. These results demonstrate that photoredox-based cross-coupling of C(sp2)?H with aryldiazonium salts can also proceed successfully under paired electrolysis conditions, thereby contributing to understanding of the parallels between photosynthesis and electrosynthesis. (Figure presented.).

ALPHA-4 INTEGRIN MEDIATED CELL ADHESION INHIBITORS FOR THE TREATMENT OR PREVENTION OF INFLAMMATORY DISEASES

The present invention relates to novel compounds of formula (I), processes for their preparation, compositions comprising them and their use in the treatment or prevention of diseases capable of being modulated by the inhibition of cell adhesion.

Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: Preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods

New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution- and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald reactions. Opioid receptor binding data for the compounds produced is reported.

Isolation and structure elucidation of a novel product of the acidic degradation of cefaclor

The acidic aqueous degradation of cefaclor, an orally administered cephalosporin antibiotic, has been investigated. The most prominent peak in the high-performance liquid chromatography profile of a degraded solution of cefaclor was isolated by preparative high-performance liquid chromatography. Mechanistically, the formation of this degradent from cefaclor involves a condensation of two cefaclor degradation products in which both products have undergone contraction from a six-membered cephem ring to a five-membered thiazole ring, presumably via a common episulfonium ion intermediate.

Novel (substituted phenyl)-1,2,4-triazolo (4,3-A)pyrazines and novel 2-hydrazino-(substituted phenyl)pyrazine intermediates

This disclosure describes novel 5-,6- and 8-(phenyl and substituted phenyl)-1,2,4-triazolo[4,3-a]pyrazines which posses utility as anxiolytic agents.

Some Reactions of Mono Substituted Pyrazine Monoxides

The reactions of the monoxides of propylpyrazine and phenylpyrazine with phosphoryl chloride or acetic anhydride were investigated.Except in the case of the reaction of 2-propylpyrazine 1-oxide with acetic anhydride, chlorination or acetoxylation occurred