1'-methyl-1-(3-phenylpropyl)-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]-pyrazole]

Base Information

Chemical Name:1'-methyl-1-(3-phenylpropyl)-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]-pyrazole]
CAS No.:1071835-91-0
Molecular Formula:C₂₀H₂₇N₃O
Molecular Weight:325.454
Hs Code.:

Synonyms:

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Chemical Property of 1'-methyl-1-(3-phenylpropyl)-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]-pyrazole]

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Technology Process of 1'-methyl-1-(3-phenylpropyl)-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]-pyrazole]

There total 9 articles about 1'-methyl-1-(3-phenylpropyl)-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]-pyrazole] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1071835-82-9
1'-methyl-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]pyrazole]

: 637-59-2
1-Bromo-3-phenylpropane

: 1071835-91-0
1'-methyl-1-(3-phenylpropyl)-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]-pyrazole]

Guidance literature:: With potassium carbonate; In acetonitrile; for 46h; Reflux;
DOI:10.1021/jm200585k

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1071835-91-0
1'-methyl-1-(3-phenylpropyl)-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]-pyrazole]

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

1.2: 21.5 h / -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / water / 47 h / 20 °C

3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere; Reflux

4.1: palladium 10% on activated carbon; hydrogen; acetic acid / 20 °C

5.1: palladium 10% on activated carbon; ammonium formate / methanol / 0.5 h / Reflux

6.1: potassium carbonate / acetonitrile / 46 h / Reflux

With hydrogenchloride; n-butyllithium; palladium 10% on activated carbon; hydrogen; ammonium formate; potassium carbonate; acetic acid; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;
DOI:10.1021/jm200585k

Reference yield:

: 1071835-98-7
2-(4-bromo-1-methylpyrazol-5-yl)acetaldehyde dimethyl acetal

: 1071835-91-0
1'-methyl-1-(3-phenylpropyl)-6',7'-dihydro-1'H-spiro[piperidine-4,4'-pyrano[4,3-c]-pyrazole]

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

1.2: 21.5 h / -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / water / 47 h / 20 °C

3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere; Reflux

4.1: palladium 10% on activated carbon; hydrogen; acetic acid / 20 °C

5.1: palladium 10% on activated carbon; ammonium formate / methanol / 0.5 h / Reflux

6.1: potassium carbonate / acetonitrile / 46 h / Reflux

With hydrogenchloride; n-butyllithium; palladium 10% on activated carbon; hydrogen; ammonium formate; potassium carbonate; acetic acid; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;
DOI:10.1021/jm200585k