diethyl N-<4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate
CAS No.:1054687-13-6
Molecular Formula:C₂₇H₃₇N₅O₅
Molecular Weight:511.621
Hs Code.:

diethyl N-<4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopenta<d>pyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate

Synonyms:

Suppliers and Price of diethyl N-<4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diethyl N-<4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diethyl N-<4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate

There total 11 articles about diethyl N-<4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105580-41-4
4-acetylbenzoic acid tert-butyl ester

: 1054687-13-6
diethyl N-<4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, 60 deg C, 3 h

2: 100 percent / H₂ / 10percent Pd/C / ethanol

3: 98 percent / 1N NaOH / ethanol / 3 h / Ambient temperature

4: 100 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / -78 - 20 °C

5: 22 g / triethylamine / CH₂Cl₂ / 1 h / -78 °C

6: 94 percent / NaI / acetone / 12 h / Heating

7: 18.8 percent / tributyltin hydride, azobisisobutyronitrile / benzene / Heating

8: 96 percent / N,N-diisopropylethylamine / hexane; ethanol; acetonitrile / 5 h / Ambient temperature

9: 51 percent / 2-methyl-propan-2-ol / 12 h / 160 °C

10: 100 percent / 1N HCl / acetic acid / 2 h / Ambient temperature

11: DPPA, Et₃N / dimethylformamide / 1.) 0 deg C, 30 min, 2.) RT, 2 h

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; diphenyl-phosphinic acid; hydrogen; tri-n-butyl-tin hydride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1248/cpb.43.829

Reference yield:

: ethyl 3-<4-(tert-butoxycarbonyl)phenyl>-3-methylacrylate

: 1054687-13-6
diethyl N-<4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / H₂ / 10percent Pd/C / ethanol

2: 98 percent / 1N NaOH / ethanol / 3 h / Ambient temperature

3: 100 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / -78 - 20 °C

4: 22 g / triethylamine / CH₂Cl₂ / 1 h / -78 °C

5: 94 percent / NaI / acetone / 12 h / Heating

6: 18.8 percent / tributyltin hydride, azobisisobutyronitrile / benzene / Heating

7: 96 percent / N,N-diisopropylethylamine / hexane; ethanol; acetonitrile / 5 h / Ambient temperature

8: 51 percent / 2-methyl-propan-2-ol / 12 h / 160 °C

9: 100 percent / 1N HCl / acetic acid / 2 h / Ambient temperature

10: DPPA, Et₃N / dimethylformamide / 1.) 0 deg C, 30 min, 2.) RT, 2 h

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; diphenyl-phosphinic acid; hydrogen; tri-n-butyl-tin hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1248/cpb.43.829

Reference yield:

: 149324-79-8
tert-butyl 4-(3-iodo-1-methylpropyl)benzoate

: 1054687-13-6
diethyl N-<4-<3-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1: 18.8 percent / tributyltin hydride, azobisisobutyronitrile / benzene / Heating

2: 96 percent / N,N-diisopropylethylamine / hexane; ethanol; acetonitrile / 5 h / Ambient temperature

3: 51 percent / 2-methyl-propan-2-ol / 12 h / 160 °C

4: 100 percent / 1N HCl / acetic acid / 2 h / Ambient temperature

5: DPPA, Et₃N / dimethylformamide / 1.) 0 deg C, 30 min, 2.) RT, 2 h

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); diphenyl-phosphinic acid; tri-n-butyl-tin hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; hexane; acetic acid; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1248/cpb.43.829