105580-41-4

Usage

Uses

Used in Chemical Research:
4-Acetyl-benzoic acid tert-butyl ester is used as a reagent in chemical research for its role in organic synthesis, facilitating the creation of various complex organic molecules.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, 4-Acetyl-benzoic acid tert-butyl ester is used as an intermediate in the synthesis of pharmaceutical compounds, contributing to the development of new drugs and medications.
Used in Fragrance Industry:
Due to its strong, often pleasant odor, 4-Acetyl-benzoic acid tert-butyl ester is used as a fragrance ingredient in the perfumery and cosmetics industry, adding unique scents to various products.

InChI:InChI=1/C13H16O3/c1-9(14)10-5-7-11(8-6-10)12(15)16-13(2,3)4/h5-8H,1-4H3

Upstream product

• 31076-84-3 4-acetylbenzoyl chloride 
• 75-65-0 tert-butyl alcohol 
• 586-89-0 4-acetyl-benzoic acid 
• 83766-88-5 2-tert-butoxypyridine 
• 65874-27-3 4-(tert-butoxycarbonyl)benzaldehyde 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 130351-30-3 ethyl 5-<4-(tert-butoxycarbonyl)phenyl>-5-hydroxy-2-hexenoate 
• 125991-45-9 ethyl 5-<4-(tert-butoxycarbonyl)phenyl>hexanoate 
• 945401-49-0 2-(4-(tert-butoxycarbonyl)phenyl)-2-oxoacetic acid 
• 117347-38-3 C₁₄H₁₈O₂ 
• 1312769-65-5 tert-butyl 4-[(1R)-1-aminoethyl]benzoate hydrochloride 
• 1312769-64-4 tert-butyl 4-(1-hydroxyethyl)benzoate 
• 1312769-66-6 tert-butyl 4-[(1R)-1-(1,3-dioxoisoindolyn-2-yl)ethyl]benzoate 
• 1620096-39-0 tert-butyl 4-(1,1,1-trifluoropropan-2-yl)benzoate 
• 1620096-77-6 C₁₄H₁₆F₂O₂ 
• 31076-84-3 4-acetylbenzoyl chloride 
• 586-89-0 4-acetyl-benzoic acid 

Relevant academic research and scientific papers

A fast and practical synthesis of tert-butyl esters from 2-tert-butoxypyridine using boron trifluoride·diethyl etherate under mild conditions

A practical direct preparation of tert-butyl esters from 2-tert-butoxypyridine has been developed. This system features the use of boron trifluoride·diethyl etherate in toluene solvent to rapidly achieve the reaction at room temperature. Using this reaction protocol, a variety of tert-butyl esters were synthesized from several different carboxylic acids at high yields. This practical procedure provides a promising and effective approach to the protection of carboxylic acids with a tert-butyl group.

Structural and mechanistic studies of the base-induced Sommelet-Hauser rearrangement of: N -α-branched benzylic azetidine-2-carboxylic acid-derived ammonium salts

The base-induced Sommelet-Hauser rearrangement of N-α-branched benzylic azetidine-2-carboxylic acid ester-derived ammonium salts to obtain α-arylazetidine-2-carboxylic acid esters was investigated. The substrates, two diastereomeric salts (1S,2S,1′S)- and (1R,2R,1′S)-2, showed different reactivities. The rearrangement of (1S,2S,1′S)-2a proceeded with a perfect N-to-C chirality transfer to provide (R)-3a in 74% yield with 99% ee. However, the rearrangement of (1R,2R,1′S)-2a under the same conditions afforded (S)-3a in only 15% yield with a lower 66% ee, along with the competitive [1,2] Stevens rearrangement product 4a. Structural and mechanistic studies of this rearrangement were carried out to clarify the exact reason. Our results define the scope and limitations of the Sommelet-Hauser rearrangement and provide unique synthetic access to α-aryl amino acid derivatives.

PENICILLIN-BINDING PROTEIN INHIBITORS

Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds describ

The Conversion of tert-Butyl Esters to Acid Chlorides Using Thionyl Chloride

The reaction of tert-butyl esters with SOCl2 at room temperature provides acid chlorides in unpurified yields of 89% or greater. Benzyl, methyl, ethyl, and isopropyl esters are essentially unreactive under these conditions, allowing for the selective conversion of tert-butyl esters to acid chlorides in the presence of other esters.

Metal-free trifluoromethylation of aromatic and heteroaromatic aldehydes and ketones

The ability to convert simple and common substrates into fluoroalkyl derivatives under mild conditions remains an important goal for medicinal and agricultural chemists. One representative example of a desirable transformation involves the conversion of aromatic and heteroaromatic ketones and aldehydes into aryl and heteroaryl β,β,β-trifluoroethylarenes and -heteroarenes. The traditional approach for this net transformation involves stoichiometric metals and/or multistep reaction sequences that consume excessive time, material, and labor resources while providing low yields of products. To complement these traditional strategies, we report a one-pot metal-free decarboxylative procedure for accessing β,β,β- trifluoroethylarenes and -heteroarenes from readily available ketones and aldehydes. This method features several benefits, including ease of operation, readily available reagents, mild reaction conditions, high functional-group compatibility, and scalability.

SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS

Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.

HYDROXYALKYLARYLAMIDE DERIVATIVES

The present invention relates to a novel class of hydroxyalkylarylamide derivatives. The instant compounds can be used to treat cancer. The fluorinated arylamide derivatives can also inhibit histone deacetylase and are suitable for use in selectively indu

NOVEL BUTADIENE DERIVATIVES, PROCESS FOR PREPARATION OF THE SAME AND INTERMEDIATES FOR THE SYNTHESIS THEREOF

A butadiene derivative having an excellent inhibitory activity on the PAI-1, which is represented by the general formula [I]: wherein R1 is a hydrogen atom or a lower alkyl group, R2 is a lower alkyl group, R3 is a lower alkoxy group, R4 is a hydrogen atom or a lower alkyl group, R5 is a lower alkyl group, or a pharmaceutically acceptable salt thereof, a process a process for preparing the same and an intermediate thereof.

Pyrido(2,3-d)pyrimidine derivatives

2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[1-(pyrido[2,3-d]pyrimidin-6-yl)alk-2-yl]-benzoyl)-L-glutamic acids, and the corresponding 5,6,7,8-tetrahydro compounds are antineoplastic agents. The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives. A typical embodiment is N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoyl)-L-glutamic acid.