Technology Process of 1-(4-Benzyloxy-3-methoxy-phenyl)-3-(2,3-bis-benzyloxy-5-hydroxymethyl-phenyl)-3-fluoro-propane-1,2-diol
There total 9 articles about 1-(4-Benzyloxy-3-methoxy-phenyl)-3-(2,3-bis-benzyloxy-5-hydroxymethyl-phenyl)-3-fluoro-propane-1,2-diol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 86 percent / potassium carbonate / dimethylformamide / 3 h / Heating
2: 91 percent / ammonium chloride / methanol / 4 h / Heating
3: 94 percent / 1.) n-butyl lithium / hexane; diethyl ether / 1.) -78 deg C, 10 min, 2.) -78 deg C to room temperature, 3 h
4: 93 percent / potassium hydroxide / ethanol / 4 h
5: 87 percent / conc. HCl / dioxane; methanol / 1.5 h / Ambient temperature
6: 92 percent / 30percent H2O2, 5percent NaOH / dioxane; methanol / 3 h / Ambient temperature
7: 1.) boron trifluoride etherate, 2.) sodium borohydride / 1.) benzene, 20 min, 2.) THF, room temperature, 2 h
With
hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; ammonium chloride; dihydrogen peroxide; potassium carbonate;
In
1,4-dioxane; methanol; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.37.1441
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 93 percent / potassium hydroxide / ethanol / 4 h
2: 87 percent / conc. HCl / dioxane; methanol / 1.5 h / Ambient temperature
3: 92 percent / 30percent H2O2, 5percent NaOH / dioxane; methanol / 3 h / Ambient temperature
4: 1.) boron trifluoride etherate, 2.) sodium borohydride / 1.) benzene, 20 min, 2.) THF, room temperature, 2 h
With
hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; dihydrogen peroxide;
In
1,4-dioxane; methanol; ethanol;
DOI:10.1248/cpb.37.1441
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 86 percent / potassium carbonate / dimethylformamide / 3 h / Heating
2: 91 percent / ammonium chloride / methanol / 4 h / Heating
3: 94 percent / 1.) n-butyl lithium / hexane; diethyl ether / 1.) -78 deg C, 10 min, 2.) -78 deg C to room temperature, 3 h
4: 93 percent / potassium hydroxide / ethanol / 4 h
5: 87 percent / conc. HCl / dioxane; methanol / 1.5 h / Ambient temperature
6: 92 percent / 30percent H2O2, 5percent NaOH / dioxane; methanol / 3 h / Ambient temperature
7: 1.) boron trifluoride etherate, 2.) sodium borohydride / 1.) benzene, 20 min, 2.) THF, room temperature, 2 h
With
hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; ammonium chloride; dihydrogen peroxide; potassium carbonate;
In
1,4-dioxane; methanol; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.37.1441
