(S)-4-((S)-2-Amino-3-benzylsulfanyl-propionylamino)-2-(toluene-4-sulfonylamino)-butyric acid benzyl ester; compound with trifluoro-acetic acid

Base Information

• Chemical Name: (S)-4-((S)-2-Amino-3-benzylsulfanyl-propionylamino)-2-(toluene-4-sulfonylamino)-butyric acid benzyl ester; compound with trifluoro-acetic acid
• CAS No.: 102830-46-6
• Molecular Formula: C₂HF₃O₂*C₂₈H₃₃N₃O₅S₂
• Molecular Weight: 669.743
• Mol file: 102830-46-6.mol

Synonyms:

Chemical Property of (S)-4-((S)-2-Amino-3-benzylsulfanyl-propionylamino)-2-(toluene-4-sulfonylamino)-butyric acid benzyl ester; compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-((S)-2-Amino-3-benzylsulfanyl-propionylamino)-2-(toluene-4-sulfonylamino)-butyric acid benzyl ester; compound with trifluoro-acetic acid

There total 3 articles about (S)-4-((S)-2-Amino-3-benzylsulfanyl-propionylamino)-2-(toluene-4-sulfonylamino)-butyric acid benzyl ester; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N2-tosyl-L-2,4-diaminobutyric acid benzyl ester hydrochloride (102830-50-2) → (S)-4-((S)-2-Amino-3-benzylsulfanyl-propionylamino)-2-(toluene-4-sulfonylamino)-butyric acid benzyl ester; compound with trifluoro-acetic acid (102830-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 11.125 g / (CH₃CH₂)3N, ClCO₂CH₂CH₃ / CH₂Cl₂ / 1.) -5 deg C, 20 min, 2.) RT, 2 h

2: anhyd. CF₃CO₂H / acetic acid / 0.5 h / Ambient temperature

With chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; In dichloromethane; acetic acid;

DOI:10.1021/jo00364a055

Reference yield:

N-tert-butyloxycarbonyl-(S)-benzyl-N-(tert-butyloxycarbonyl)-D-cysteine (102830-49-9) → (S)-4-((S)-2-Amino-3-benzylsulfanyl-propionylamino)-2-(toluene-4-sulfonylamino)-butyric acid benzyl ester; compound with trifluoro-acetic acid (102830-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 11.125 g / (CH₃CH₂)3N, ClCO₂CH₂CH₃ / CH₂Cl₂ / 1.) -5 deg C, 20 min, 2.) RT, 2 h

2: anhyd. CF₃CO₂H / acetic acid / 0.5 h / Ambient temperature

With chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; In dichloromethane; acetic acid;

DOI:10.1021/jo00364a055

Reference yield:

N2-tosyl-N4-(N-t-BOC-S-benzyl-D-cysteinyl)-L-2,4-diaminobutyrate benzyl ester (102830-44-4) + trifluoroacetic acid (76-05-1) → (S)-4-((S)-2-Amino-3-benzylsulfanyl-propionylamino)-2-(toluene-4-sulfonylamino)-butyric acid benzyl ester; compound with trifluoro-acetic acid (102830-46-6)

Guidance literature:

With trifluoroacetic acid; In acetic acid; for 0.5h; Ambient temperature;

DOI:10.1021/jo00364a055

upstream raw materials:

N²-tosyl-N⁴-(N-t-BOC-S-benzyl-D-cysteinyl)-L-2,4-diaminobutyrate benzyl ester

trifluoroacetic acid

N²-tosyl-L-2,4-diaminobutyric acid benzyl ester hydrochloride

N-tert-butyloxycarbonyl-(S)-benzyl-N-(tert-butyloxycarbonyl)-D-cysteine

Downstream raw materials:

N²-tosyl-N⁴-(N-benzylmalonyl-S-benzyl-D-cysteinyl)-L-2,4-diaminobutyric acid benzyl ester