1-(3,5-dimethyl-4-propionylamino)benzoyl-4-(N-methyl-2-phenylethyl)aminopiperidine

Base Information

• Chemical Name: 1-(3,5-dimethyl-4-propionylamino)benzoyl-4-(N-methyl-2-phenylethyl)aminopiperidine
• CAS No.: 167626-17-7
• Molecular Formula: C₂₆H₃₅N₃O₂
• Molecular Weight: 421.583
• Mol file: 167626-17-7.mol

Synonyms:

Chemical Property of 1-(3,5-dimethyl-4-propionylamino)benzoyl-4-(N-methyl-2-phenylethyl)aminopiperidine

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,5-dimethyl-4-propionylamino)benzoyl-4-(N-methyl-2-phenylethyl)aminopiperidine

There total 9 articles about 1-(3,5-dimethyl-4-propionylamino)benzoyl-4-(N-methyl-2-phenylethyl)aminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 1-(3,5-dimethyl-4-propionylamino)benzoyl-4-(N-methyl-2-phenylethyl)aminopiperidine (167626-17-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: AcOH; H₂ / Pt/C / ethanol / 2 h / 40 °C / 760 Torr

2.1: formic acid; H₂O / 1 h / 50 °C

2.2: 66 percent / H₂; HCl / Pd/C / ethanol / 3 h / 40 °C / 760 Torr

3.1: Et₃N; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 1 h / 20 °C

With formic acid; water; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic acid; triethylamine; platinum on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm020597o

Reference yield:

methyl 4-amino-3-methylbenzoate (18595-14-7) → 1-(3,5-dimethyl-4-propionylamino)benzoyl-4-(N-methyl-2-phenylethyl)aminopiperidine (167626-17-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-chlorosuccinimide / CH₂Cl₂ / 0.5 h / 20 °C

1.2: 48 percent / Et₃N / 5 h / Heating

2.1: 88 percent / H₂ / Raney Ni / ethanol / 1 h / 20 °C

3.1: Et₃N / CH₂Cl₂ / 2.5 h / 20 °C

4.1: aq. NaOH / methanol / 4.5 h

5.1: Et₃N; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 1 h / 20 °C

With sodium hydroxide; N-chloro-succinimide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; nickel; In methanol; ethanol; dichloromethane; 1.1: Gassman reaction;

DOI:10.1021/jm020597o

Reference yield:

phenethylamine (64-04-0) → 1-(3,5-dimethyl-4-propionylamino)benzoyl-4-(N-methyl-2-phenylethyl)aminopiperidine (167626-17-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: AcOH; H₂ / Pt/C / ethanol / 2 h / 40 °C / 760 Torr

2.1: formic acid; H₂O / 1 h / 50 °C

2.2: 66 percent / H₂; HCl / Pd/C / ethanol / 3 h / 40 °C / 760 Torr

3.1: Et₃N; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 1 h / 20 °C

With formic acid; water; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic acid; triethylamine; platinum on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm020597o

upstream raw materials:

4-[N-methyl-N-(2-phenylethyl)amino]piperidine

3,5-dimethyl-4-propionylaminobenzoic acid

1-phenylmethyl-4-piperidone

4-amino-3,5-dimethyl-benzoic acid methyl ester