(S)-N-(tert-butoxycarbonyl)methionine amide

Base Information

• Chemical Name: (S)-N-(tert-butoxycarbonyl)methionine amide
• CAS No.: 34805-23-7
• Molecular Formula: C₁₀H₂₀N₂O₃S
• Molecular Weight: 248.346
• Mol file: 34805-23-7.mol

Synonyms:

Chemical Property of (S)-N-(tert-butoxycarbonyl)methionine amide

Chemical Property:

• Melting Point: 161.2 °C
• Boiling Point: 434.7±40.0 °C(Predicted)
• Density: 1.123±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

BOC-MET-NH2 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-N-(tert-butoxycarbonyl)methionine amide

There total 7 articles about (S)-N-(tert-butoxycarbonyl)methionine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-tert-butoxycarbonyl-L-methionine (2488-15-5) → (S)-N-(tert-butoxycarbonyl)methionine amide (34805-23-7)

Guidance literature:

N-tert-butoxycarbonyl-L-methionine; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

With ammonium chloride; In tetrahydrofuran; water; at 0 ℃; for 0.5h;

DOI:10.1016/j.tetasy.2017.10.015

Reference yield: 79.0%

C15H27NO6S (84890-95-9) → (S)-N-(tert-butoxycarbonyl)methionine amide (34805-23-7)

Guidance literature:

With ammonia; In water; at -25 - 20 ℃;

DOI:10.1002/cmdc.201500151

Reference yield: 73.0%

tertbutoxycarbonyl-L-methionine N-hydroxysuccinimide ester (3845-64-5) → (S)-N-(tert-butoxycarbonyl)methionine amide (34805-23-7)

Guidance literature:

With ammonium hydroxide; In N,N-dimethyl-formamide; at 0 ℃; for 24h;

upstream raw materials:

N-tert-butoxycarbonyl-L-methionine

C₁₅H₂₇NO₆S

di-tert-butyl dicarbonate

tertbutoxycarbonyl-L-methionine N-hydroxysuccinimide ester

Downstream raw materials:

N-tert-butoxycarbonyl-L-leucyl-L-methioninamide

(S)-methioninamide hydrochloride