cis-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methyl benzoate

Base Information

• Chemical Name: cis-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methyl benzoate
• CAS No.: 145782-12-3
• Molecular Formula: C₂₇H₂₄N₂O₄
• Molecular Weight: 440.499
• Mol file: 145782-12-3.mol

Synonyms:

Chemical Property of cis-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methyl benzoate

There total 8 articles about cis-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

1H-imidazole (288-32-4) + cis/trans-<2-(1,1'-biphenyl-4-yl)-2-bromomethyl-1,3-dioxolan-4-yl>methyl benzoate (145782-11-2,145782-34-9) → trans-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methyl benzoate (145782-12-3,145782-14-5) + cis-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methyl benzoate (145782-12-3,145782-14-5)

Guidance literature:

In N,N-dimethyl acetamide; for 96h; Heating;

DOI:10.1002/ardp.19923251102

Reference yield: 28.0%

1H-imidazole (288-32-4) + cis/trans-<2-(1,1'-biphenyl-4-yl)-2-bromomethyl-1,3-dioxolan-4-yl>methyl benzoate (145782-11-2,145782-34-9) → trans-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methyl benzoate (145782-12-3,145782-14-5) + cis-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methyl benzoate (145782-12-3,145782-14-5)

Guidance literature:

In N,N-dimethyl acetamide; for 96h; Heating;

DOI:10.1002/ardp.19923251102

Reference yield:

benzoyl chloride (98-88-4) → trans-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methyl benzoate (145782-12-3,145782-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 39.0 g / pyridine / 2.5 h / 0 °C

2: 12 percent / N,N-dimethyl-acetamide / 96 h / Heating

With pyridine; In N,N-dimethyl acetamide;

DOI:10.1002/ardp.19923251102

upstream raw materials:

1H-imidazole

cis/trans-<2-(1,1'-biphenyl-4-yl)-2-bromomethyl-1,3-dioxolan-4-yl>methyl benzoate

benzoyl chloride

2-Bromo-4'-phenylacetophenone

Downstream raw materials:

cis-1-acetyl-4-<-<<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>piperazine

cis-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methyl methanesulfonate

cis-<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methanol

trans-1-acetyl-4-<-<<2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>piperazine