fentanyl citrate

Base Information

• Chemical Name: fentanyl citrate
• CAS No.: 1863-07-6
• Molecular Formula: C₆H₈O₇*C₂₂H₂₈N₂O
• Molecular Weight: 528.602
• Mol file: 1863-07-6.mol

Synonyms:

Chemical Property of fentanyl citrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of fentanyl citrate

There total 6 articles about fentanyl citrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]propanamide (437-38-7) + citric acid (77-92-9,906507-37-7) → fentanyl citrate (1863-07-6,990-73-8)

Guidance literature:

In methanol; at 20 ℃; for 2h;

DOI:10.1371/journal.pone.0108250

Reference yield:

4-piperidone hydrochloride (41979-39-9) → fentanyl citrate (1863-07-6,990-73-8)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile / 5 h / 80 °C

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

4: methanol / 2 h / 20 °C

With sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;

DOI:10.1371/journal.pone.0108250

Reference yield:

1-phenyl-2-bromoethane (103-63-9) → fentanyl citrate (1863-07-6,990-73-8)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile / 5 h / 80 °C

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

4: methanol / 2 h / 20 °C

With sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;

DOI:10.1371/journal.pone.0108250

upstream raw materials:

N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]propanamide

citric acid

4-piperidone hydrochloride

1-phenyl-2-bromoethane

Downstream raw materials:

N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]propanamide

Refernces

• 1、 -. "SUBSTITUTED 4-AMINO-PIPERIDINES". Page/Page column 20. . Retrieved 2010/02/17.