5'-O-acetyl-N¹-benzyl-2',3'-O-benzylidene guanosine

Base Information

• Chemical Name: 5'-O-acetyl-N¹-benzyl-2',3'-O-benzylidene guanosine
• CAS No.: 219724-70-6
• Molecular Formula: C₂₆H₂₅N₅O₆
• Molecular Weight: 503.514
• Mol file: 219724-70-6.mol

Synonyms:

Chemical Property of 5'-O-acetyl-N¹-benzyl-2',3'-O-benzylidene guanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-acetyl-N¹-benzyl-2',3'-O-benzylidene guanosine

There total 4 articles about 5'-O-acetyl-N¹-benzyl-2',3'-O-benzylidene guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetic anhydride (108-24-7) + 1-benzyl-9-(2',3'-O-benzylidene-β-D-ribofuranosyl)guanine (214918-86-2) → 5'-O-acetyl-N1-benzyl-2',3'-O-benzylidene guanosine (219724-70-6)

Guidance literature:

With triethylamine;

DOI:10.1016/S0040-4039(98)02074-7

Reference yield:

benzaldehyde (100-52-7) → 5'-O-acetyl-N1-benzyl-2',3'-O-benzylidene guanosine (219724-70-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / ZnCl₂ / 25 °C

2: 64 percent / NaH

3: 98 percent / Et₃N

With sodium hydride; triethylamine; zinc(II) chloride;

DOI:10.1016/S0040-4039(98)02074-7

Reference yield:

G (118-00-3) → 5'-O-acetyl-N1-benzyl-2',3'-O-benzylidene guanosine (219724-70-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / ZnCl₂ / 25 °C

2: 64 percent / NaH

3: 98 percent / Et₃N

With sodium hydride; triethylamine; zinc(II) chloride;

DOI:10.1016/S0040-4039(98)02074-7

upstream raw materials:

acetic anhydride

1-benzyl-9-(2',3'-O-benzylidene-β-D-ribofuranosyl)guanine

benzaldehyde

G