(R_P)-(L-menthyl)methylphenylphosphine

Base Information

• Chemical Name: (R_P)-(L-menthyl)methylphenylphosphine
• CAS No.: 65440-74-6
• Molecular Formula: C₁₇H₂₇P
• Molecular Weight: 262.375
• Mol file: 65440-74-6.mol

Synonyms:

Chemical Property of (R_P)-(L-menthyl)methylphenylphosphine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R_P)-(L-menthyl)methylphenylphosphine

There total 12 articles about (R_P)-(L-menthyl)methylphenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(RP)-Menthylmethylphenylphosphine Oxide (65440-75-7) → (SP)-Menthylmethylphenylphosphine (65440-73-5,65440-74-6)

Guidance literature:

With hexachlorodisilane; In benzene; at 80 ℃; for 0.166667h;

DOI:10.1021/jo01306a030

Reference yield: 58.0%

(SP)-(-)-menthyl methylphenylphosphine oxide (65440-76-8) → (SP)-Menthylmethylphenylphosphine (65440-73-5,65440-74-6)

Guidance literature:

With hexachlorodisilane; In benzene; at 80 ℃; for 0.166667h;

DOI:10.1021/jo01306a030

Reference yield:

RP-(-)-menthyl phenylphosphine oxide → (SP)-Menthylmethylphenylphosphine (65440-73-5,65440-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / tetrahydrofuran / 0.02 h / 20 °C / Inert atmosphere; Schlenk technique

2: diethyl ether / 8 h / -80 - 20 °C / Inert atmosphere; Schlenk technique

With oxalyl dichloride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/acs.orglett.7b02667

upstream raw materials:

(S_P)-(-)-menthyl methylphenylphosphine oxide

(R_P)-Menthylmethylphenylphosphine Oxide

methylmagnesium bromide

(R_P)-O-(-)-menthyl phenylphosphine oxide

Downstream raw materials:

(R_P)-Menthylmethylphenylphosphine Oxide

(S_P)-(-)-menthyl methylphenylphosphine oxide