65440-76-8

Basic information

• Product Name: (S_P)-(-)-menthyl methylphenylphosphine oxide
• Synonyms: (S_P)-(-)-menthyl methylphenylphosphine oxide
• CAS NO: 65440-76-8
• Molecular Weight: 278.375
• Mol File: 65440-76-8.mol

Chemical Properties

• CAS DataBase Reference: (S_P)-(-)-menthyl methylphenylphosphine oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (S_P)-(-)-menthyl methylphenylphosphine oxide(65440-76-8)
• EPA Substance Registry System: (S_P)-(-)-menthyl methylphenylphosphine oxide(65440-76-8)

Safety Data

• Hazardous Substances Data: 65440-76-8(Hazardous Substances Data)

Upstream product

• 75-16-1 methylmagnesium bromide 
• 55266-95-0 L-menthylphenylchlorophosphine 
• 65440-75-7 (R_P)-Menthylmethylphenylphosphine Oxide 
• 74298-28-5 Neomenthylmethyldiphenylphosphonium Iodide 
• 65440-73-5 (S_P)-Menthylmethylphenylphosphine 

Downstream Products

• 65440-73-5 (S_P)-Menthylmethylphenylphosphine 
• 65440-75-7 (R_P)-Menthylmethylphenylphosphine Oxide 

Relevant articles and documents

Nucleophilic substitution of p-stereogenic chlorophosphines: Mechanism, stereochemistry, and stereoselective conversions of diastereomeric secondary phosphine oxides to tertiary phosphines

A diastereomeric mixture of secondary phosphine oxide is stereospecifically converted to chlorophosphine salt by treatment with oxalyl chloride, which stereoselectively affords P-inverted or retained tertiary phosphines, depending on the substitution with aliphatic or aromatic Grignard reagents, respectively, in high to 99% yield and 99:1 dr. The repulsion of π- electron on aryl to lone electron pair on phosphorus is proposed for the P-retained substitution.

Synthesis of Phosphines Having Chiral Organic Groups Ligated to Chiral Phosphorus

Both R and S phosphorus epimers of menthylmethylphenylphosphine and its phoshine oxide and of neomenthylmethylphenylphosphine and its phosphine oxide were prepared.The menthylmethylphenylphosphine oxides were prepared from neomenthyldiphenylphosphine by a