3-Hydroxy-7-(tetrahydro-pyran-2-yloxy)-2-trimethylsilanylmethyl-heptanoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Base Information

Chemical Name:3-Hydroxy-7-(tetrahydro-pyran-2-yloxy)-2-trimethylsilanylmethyl-heptanoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester
CAS No.:133124-93-3
Molecular Formula:C₃₂H₅₄O₅Si
Molecular Weight:546.863
Hs Code.:

3-Hydroxy-7-(tetrahydro-pyran-2-yloxy)-2-trimethylsilanylmethyl-heptanoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

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Chemical Property of 3-Hydroxy-7-(tetrahydro-pyran-2-yloxy)-2-trimethylsilanylmethyl-heptanoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

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Technology Process of 3-Hydroxy-7-(tetrahydro-pyran-2-yloxy)-2-trimethylsilanylmethyl-heptanoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

There total 4 articles about 3-Hydroxy-7-(tetrahydro-pyran-2-yloxy)-2-trimethylsilanylmethyl-heptanoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17728-88-0
ethyl 3-(trimethylsilyl)propionate

: 133124-93-3
3-Hydroxy-7-(tetrahydro-pyran-2-yloxy)-2-trimethylsilanylmethyl-heptanoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / KOH / ethanol

2: 90 percent / SOCl₂

3: 100 percent / pyridine

4: 1) LDA / 1, 2) THF, -78 deg C

With pyridine; potassium hydroxide; thionyl chloride; lithium diisopropyl amide; In ethanol;
DOI:10.1016/S0040-4039(00)92635-2

Reference yield:

: 18187-31-0
3-(trimethylsilyl)propanoyl chloride

: 133124-93-3
3-Hydroxy-7-(tetrahydro-pyran-2-yloxy)-2-trimethylsilanylmethyl-heptanoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / pyridine

2: 1) LDA / 1, 2) THF, -78 deg C

With pyridine; lithium diisopropyl amide;
DOI:10.1016/S0040-4039(00)92635-2

Reference yield:

: 5683-30-7
3-trimethylsilylpropionic acid

: 133124-93-3
3-Hydroxy-7-(tetrahydro-pyran-2-yloxy)-2-trimethylsilanylmethyl-heptanoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / SOCl₂

2: 100 percent / pyridine

3: 1) LDA / 1, 2) THF, -78 deg C

With pyridine; thionyl chloride; lithium diisopropyl amide;
DOI:10.1016/S0040-4039(00)92635-2