cyclo-[N-({2-[-4)-2,3-O-isopropylidene-D-gluco-pentitol-1-yl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl-(1->O}acetyl)glycyl-L-phenylalanyl-L-leucyl-]

Base Information

• Chemical Name: cyclo-[N-({2-[-4)-2,3-O-isopropylidene-D-gluco-pentitol-1-yl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl-(1->O}acetyl)glycyl-L-phenylalanyl-L-leucyl-]
• CAS No.: 313966-88-0
• Molecular Formula: C₃₇H₄₉N₅O₁₁
• Molecular Weight: 739.823
• Mol file: 313966-88-0.mol

Synonyms:

Chemical Property of cyclo-[N-({2-[-4)-2,3-O-isopropylidene-D-gluco-pentitol-1-yl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl-(1->O}acetyl)glycyl-L-phenylalanyl-L-leucyl-]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclo-[N-({2-[-4)-2,3-O-isopropylidene-D-gluco-pentitol-1-yl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl-(1->O}acetyl)glycyl-L-phenylalanyl-L-leucyl-]

There total 2 articles about cyclo-[N-({2-[-4)-2,3-O-isopropylidene-D-gluco-pentitol-1-yl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl-(1->O}acetyl)glycyl-L-phenylalanyl-L-leucyl-] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

acetone (67-64-1) + cyclo-[N-({2-[-5)-D-gluco-pentitol-1-yl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl-(1->O}acetyl)glycyl-L-phenylalanyl-L-leucyl-] (213819-12-6) → cyclo-[N-({2-[-4)-2,3-O-isopropylidene-D-gluco-pentitol-1-yl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl-(1->O}acetyl)glycyl-L-phenylalanyl-L-leucyl-] (313966-88-0) + cyclo-[N-({2-[-5)-2,3-O-isopropylidene-D-gluco-pentitol-1-yl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl-(1->O}acetyl)glycyl-L-phenylalanyl-L-leucyl-] (313966-86-8)

Guidance literature:

With sulfuric acid; at 20 ℃; for 4h;

Reference yield:

6-O-(L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl)-D-glucopyranose (183812-37-5) → cyclo-[N-({2-[-4)-2,3-O-isopropylidene-D-gluco-pentitol-1-yl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl-(1->O}acetyl)glycyl-L-phenylalanyl-L-leucyl-] (313966-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / methanol / 72 h / 60 °C

2: 24 percent / H₂SO₄ / 4 h / 20 °C

With sulfuric acid; In methanol; 1: cyclocondensation / 2: condensation;

Reference yield: 52.0%

cyclo-[N-({2-[-4)-2,3-O-isopropylidene-D-gluco-pentitol-1-yl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl-(1->O}acetyl)glycyl-L-phenylalanyl-L-leucyl-] (313966-88-0) → N-{[2-(2,3-O-isopropylidene-D-gluco-pentitol-1-yl)-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl]acetyl}glycyl-L-phenylalanyl-L-leucine

Guidance literature:

With ammonium hydroxide; at 20 ℃; for 2h;

upstream raw materials:

acetone

cyclo-[N-({2-[-5)-D-gluco-pentitol-1-yl]-4-(4-hydroxybenzyl)-5-oxoimidazolidin-1-yl-(1->O}acetyl)glycyl-L-phenylalanyl-L-leucyl-]

6-O-(L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl)-D-glucopyranose