C₂₀H₂₇NOS

Base Information

Chemical Name:C₂₀H₂₇NOS
CAS No.:1276115-01-5
Molecular Formula:C₂₀H₂₇NOS
Molecular Weight:329.506
Hs Code.:

Synonyms:

Suppliers and Price of C₂₀H₂₇NOS

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₀H₂₇NOS

Chemical Property:

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Technology Process of C₂₀H₂₇NOS

There total 11 articles about C₂₀H₂₇NOS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1276114-99-8
C₁₉H₂₇NOS

: 1276115-01-5
C₂₀H₂₇NOS

Guidance literature:: With toluene-4-sulfonic acid; In chloroform; at 65 ℃; for 16h;
DOI:10.1021/jo2000868

Reference yield:

: 188692-78-6
(3S)-4-(tert-butyldimethylsilanyloxy)-3-methylbutyronitrile

: 1276115-01-5
C₂₀H₂₇NOS

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 16 h / -78 - 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / Molecular sieve

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.58 h / -78 - 20 °C

3.2: 16 h / -78 - 20 °C

4.1: tetrachloromethane / dichloromethane / 72 h / 0 °C

5.1: diisobutylaluminium hydride / hexanes; dichloromethane / 1.5 h / -78 °C

5.2: 0.5 h

6.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / toluene / 16 h / 60 °C

7.1: toluene / 16 h / Reflux

8.1: acetic acid; zinc / water / 2 h / 70 °C

9.1: toluene-4-sulfonic acid / chloroform / 16 h / 65 °C

With tetrachloromethane; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; isopropylmagnesium chloride; diisobutylaluminium hydride; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; lithium diisopropyl amide; In tetrahydrofuran; hexanes; dichloromethane; chloroform; water; toluene;
DOI:10.1021/jo2000868

Reference yield:

: 1276114-91-0
5-(cyclopent-1-en-1-yl)-2-((R)-1-hydroxypropan-2-yl)-2-(phenylthio)pentanenitrile

: 1276115-01-5
C₂₀H₂₇NOS

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrachloromethane / dichloromethane / 72 h / 0 °C

2.1: diisobutylaluminium hydride / hexanes; dichloromethane / 1.5 h / -78 °C

2.2: 0.5 h

3.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / toluene / 16 h / 60 °C

4.1: toluene / 16 h / Reflux

5.1: acetic acid; zinc / water / 2 h / 70 °C

6.1: toluene-4-sulfonic acid / chloroform / 16 h / 65 °C

With tetrachloromethane; hydroxylamine hydrochloride; diisobutylaluminium hydride; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In hexanes; dichloromethane; chloroform; water; toluene;
DOI:10.1021/jo2000868