C₁₃H₁₃F₂N₃O

Base Information

Chemical Name:C₁₃H₁₃F₂N₃O
CAS No.:1404115-75-8
Molecular Formula:C₁₃H₁₃F₂N₃O
Molecular Weight:265.263
Hs Code.:

C<sub>13</sub>H<sub>13</sub>F<sub>2</sub>N<sub>3</sub>O

Synonyms:

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Chemical Property of C₁₃H₁₃F₂N₃O

Chemical Property:

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Technology Process of C₁₃H₁₃F₂N₃O

There total 3 articles about C₁₃H₁₃F₂N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404115-27-0
2-(2-bromophenyl)-2,2-difluoroethanamine

: 1404115-75-8
C₁₃H₁₃F₂N₃O

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0.75 h / 21 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 4 h / Inert atmosphere; Heating

3: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol / Heating

4: trifluoroacetic acid / dichloromethane

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; isopropyl alcohol; 2: |Suzuki Coupling / 3: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.08.031

Reference yield:

: 1180536-37-1
ethyl 2-(2-bromophenyl)-2,2-difluoro-acetate

: 1404115-75-8
C₁₃H₁₃F₂N₃O

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonia / methanol / 1 h / 21 °C

2.1: borane-THF / tetrahydrofuran / 2.5 h / Reflux; Inert atmosphere

2.2: 2 h / 50 °C / Inert atmosphere

2.3: 20 °C / pH 10

3.1: triethylamine / dichloromethane / 0.75 h / 21 °C

4.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 4 h / Inert atmosphere; Heating

5.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol / Heating

6.1: trifluoroacetic acid / dichloromethane

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; borane-THF; ammonia; potassium acetate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol; 4.1: |Suzuki Coupling / 5.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.08.031

Reference yield:

: 1375471-74-1
2-(2-bromophenyl)-2,2-difluoroacetamide

: 1404115-75-8
C₁₃H₁₃F₂N₃O

Guidance literature:: Multi-step reaction with 5 steps

1.1: borane-THF / tetrahydrofuran / 2.5 h / Reflux; Inert atmosphere

1.2: 2 h / 50 °C / Inert atmosphere

1.3: 20 °C / pH 10

2.1: triethylamine / dichloromethane / 0.75 h / 21 °C

3.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 4 h / Inert atmosphere; Heating

4.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol / Heating

5.1: trifluoroacetic acid / dichloromethane

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; borane-THF; potassium acetate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol; 3.1: |Suzuki Coupling / 4.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.08.031