2,2-Dimethyl-succinic acid 4-{(1S,2S)-1-((R)-4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl} ester

Base Information

• Chemical Name: 2,2-Dimethyl-succinic acid 4-{(1S,2S)-1-((R)-4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl} ester
• CAS No.: 343330-26-7
• Molecular Formula: C₃₆H₄₉N₃O₈S
• Molecular Weight: 683.866
• Mol file: 343330-26-7.mol

Synonyms:

Chemical Property of 2,2-Dimethyl-succinic acid 4-{(1S,2S)-1-((R)-4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl} ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-succinic acid 4-{(1S,2S)-1-((R)-4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl} ester

There total 1 articles about 2,2-Dimethyl-succinic acid 4-{(1S,2S)-1-((R)-4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dimethylsuccinic anhydride (17347-61-4) + KNI-727 (189357-33-3) → 2,2-Dimethyl-succinic acid 4-{(1S,2S)-1-((R)-4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl} ester (343330-26-7)

Guidance literature:

With N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; diethyl ether;

DOI:10.1016/S0960-894X(01)00007-5

Reference yield:

2,2-Dimethyl-succinic acid 4-{(1S,2S)-1-((R)-4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl} ester (343330-26-7) → N-(2-amino-ethyl)-3,3-dimethyl-succinamic acid 1-(4-tert-butylcarbamoyl-5,5-dimethyl-thiazolidine-3-carbonyl)-2-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-phenyl-propyl ester; hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: EDC*HCl; HOBt / dimethylformamide

2: 4 N aq. HCl / dioxane

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00007-5

upstream raw materials:

2,2-dimethylsuccinic anhydride

KNI-727