C₈H₇ClN₄O₃

Base Information

• Chemical Name: C₈H₇ClN₄O₃
• CAS No.: 1279718-30-7
• Molecular Formula: C₈H₇ClN₄O₃
• Molecular Weight: 242.622
• Mol file: 1279718-30-7.mol

Synonyms:

Chemical Property of C₈H₇ClN₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₈H₇ClN₄O₃

There total 2 articles about C₈H₇ClN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

nitromethane (75-52-5) + 2-azido 5-chlorobenzaldehyde (916664-23-8) → C8H7ClN4O3 (1279718-30-7)

Guidance literature:

nitromethane; 2-azido-5-chlorobenzaldehyde; With potassium hydroxide; In ethanol; for 1h; Inert atmosphere; Cooling with ice;

With acetic acid; In ethanol; water;

DOI:10.1021/ja111060q

Reference yield:

5-chloro-2-nitrobenzaldehyde (6628-86-0) → C8H7ClN4O3 (1279718-30-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N,N,N,N,N-hexamethylphosphoric triamide / 0 - 20 °C / Inert atmosphere

2: potassium hydroxide / ethanol / 1 h / Inert atmosphere; Cooling with ice

With sodium azide; potassium hydroxide; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; 2: Henry reaction / 2: Henry reaction;

DOI:10.1021/ja111060q

Reference yield: 67.0%

C8H7ClN4O3 (1279718-30-7) → C8H5ClN4O2

Guidance literature:

With pyridine; acetic anhydride; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja111060q

upstream raw materials:

nitromethane

2-azido 5-chlorobenzaldehyde

5-chloro-2-nitrobenzaldehyde

Downstream raw materials:

5-chloro-3-nitro-1H-indole

Refernces