(-)-4-[(3R)-3-{[5-(4-Ethylphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butanoic acid methyl ester

Base Information

Chemical Name:(-)-4-[(3R)-3-{[5-(4-Ethylphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butanoic acid methyl ester
CAS No.:1073134-94-7
Molecular Formula:C₃₀H₃₃N₃O₄
Molecular Weight:499.61
Hs Code.:

Synonyms:

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Chemical Property of (-)-4-[(3R)-3-{[5-(4-Ethylphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butanoic acid methyl ester

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Technology Process of (-)-4-[(3R)-3-{[5-(4-Ethylphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butanoic acid methyl ester

There total 9 articles about (-)-4-[(3R)-3-{[5-(4-Ethylphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1073136-02-3
(+)-4-[(3R)-3-(benzyloxy)piperidin-1-yl]butanoic acid methyl ester

: 1073134-94-7
(-)-4-[(3R)-3-{[5-(4-Ethylphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; acetic acid / palladium 10% on activated carbon / acetic acid / 20 °C

2: phosphazene base-P₄-tert-butyl / N,N-dimethyl-formamide; hexane / 4 h / 20 °C / Cooling with ice

With hydrogen; acetic acid; phosphazene base-P₄-tert-butyl; palladium 10% on activated carbon; In hexane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 85275-45-2
N-tert-butoxycarbonyl-3-piperidinol

: 1073134-94-7
(-)-4-[(3R)-3-{[5-(4-Ethylphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / toluene; water / 4 h / 70 °C

2.1: Daicel Chiralpak AS-H / isopropyl alcohol; 2-Methylpentane / 28 °C / Resolution of racemate

3.1: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

3.2: 3 h / Reflux

4.1: hydrogen; acetic acid / palladium 10% on activated carbon / acetic acid / 20 °C

5.1: phosphazene base-P₄-tert-butyl / N,N-dimethyl-formamide; hexane / 4 h / 20 °C / Cooling with ice

With hydrogen; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; phosphazene base-P₄-tert-butyl; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In hexane; 2-Methylpentane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 1073135-99-5
tert-butyl (+/-)-3-(benzyloxy)piperidinecarbamate

: 1073134-94-7
(-)-4-[(3R)-3-{[5-(4-Ethylphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Daicel Chiralpak AS-H / isopropyl alcohol; 2-Methylpentane / 28 °C / Resolution of racemate

2.1: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

2.2: 3 h / Reflux

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / acetic acid / 20 °C

4.1: phosphazene base-P₄-tert-butyl / N,N-dimethyl-formamide; hexane / 4 h / 20 °C / Cooling with ice

With hydrogen; acetic acid; phosphazene base-P₄-tert-butyl; trifluoroacetic acid; palladium 10% on activated carbon; In hexane; 2-Methylpentane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;