tert-butyl (+/-)-3-(benzyloxy)piperidinecarbamate

Base Information

Chemical Name:tert-butyl (+/-)-3-(benzyloxy)piperidinecarbamate
CAS No.:1073135-99-5
Molecular Formula:C₁₇H₂₅NO₃
Molecular Weight:291.39
Hs Code.:

Synonyms:tert-butyl (+/-)-3-(benzyloxy)piperidinecarbamate

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Chemical Property of tert-butyl (+/-)-3-(benzyloxy)piperidinecarbamate

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Technology Process of tert-butyl (+/-)-3-(benzyloxy)piperidinecarbamate

There total 1 articles about tert-butyl (+/-)-3-(benzyloxy)piperidinecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

: 100-39-0
benzyl bromide

: 85275-45-2
N-tert-butoxycarbonyl-3-piperidinol

: 1073135-99-5
tert-butyl (+/-)-3-(benzyloxy)piperidinecarbamate

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In water; toluene; at 70 ℃; for 4h;

Reference yield: 43.3%

: 1073135-99-5
tert-butyl (+/-)-3-(benzyloxy)piperidinecarbamate

: 1073136-01-2
tert-butyl (+)-(3S)-3-(benzyloxy)piperidine carbamate

: 1073136-00-1
tert-butyl (-)-(3R)-3-(benzyloxy)piperidine carbamate

Guidance literature:: With Daicel Chiralpak AS-H; In 2-Methylpentane; isopropyl alcohol; at 28 ℃; Purification / work up; Resolution of racemate;

Reference yield:

: 1073135-99-5
tert-butyl (+/-)-3-(benzyloxy)piperidinecarbamate

: 1073134-94-7
(-)-4-[(3R)-3-{[5-(4-Ethylphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Daicel Chiralpak AS-H / isopropyl alcohol; 2-Methylpentane / 28 °C / Resolution of racemate

2.1: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

2.2: 3 h / Reflux

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / acetic acid / 20 °C

4.1: phosphazene base-P₄-tert-butyl / N,N-dimethyl-formamide; hexane / 4 h / 20 °C / Cooling with ice

With hydrogen; acetic acid; phosphazene base-P₄-tert-butyl; trifluoroacetic acid; palladium 10% on activated carbon; In hexane; 2-Methylpentane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;