Technology Process of Methyl cis-3-(Boc-aMino)-2,2-diMethylcyclobutanecarboxylate
There total 6 articles about Methyl cis-3-(Boc-aMino)-2,2-diMethylcyclobutanecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
benzyl (1S,3R)-3-methoxycarbonyl-2,2-dimethylcyclobutyl-1-carbamate;
With
hydrogen;
palladium on carbon;
In
ethyl acetate;
at 20 ℃;
for 3h;
di-tert-butyl dicarbonate;
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium periodate; water / ruthenium(III) trichloride hydrate / tetrachloromethane; acetonitrile / 12 h / 0 - 20 °C
2.1: chloroformic acid ethyl ester; triethylamine / acetone / 3 h / 0 °C
2.2: 1.5 h / 0 - 20 °C
3.1: toluene / 4 h / 0 °C / Reflux
4.1: sodium hydroxide; bromine / water / 5 h / -5 °C
4.2: pH 2 - 3
5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C
6.1: hydrogen / palladium on carbon / ethyl acetate / 3 h / 20 °C
6.2: 12 h / 0 - 20 °C
With
sodium periodate; water; hydrogen; bromine; chloroformic acid ethyl ester; caesium carbonate; triethylamine; sodium hydroxide;
ruthenium(III) trichloride hydrate; palladium on carbon;
In
tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
4.1: Lieben degradation;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: chloroformic acid ethyl ester; triethylamine / acetone / 3 h / 0 °C
1.2: 1.5 h / 0 - 20 °C
2.1: toluene / 4 h / 0 °C / Reflux
3.1: sodium hydroxide; bromine / water / 5 h / -5 °C
3.2: pH 2 - 3
4.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C
5.1: hydrogen / palladium on carbon / ethyl acetate / 3 h / 20 °C
5.2: 12 h / 0 - 20 °C
With
hydrogen; bromine; chloroformic acid ethyl ester; caesium carbonate; triethylamine; sodium hydroxide;
palladium on carbon;
In
water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene;
3.1: Lieben degradation;
