C₂₈H₂₆Cl₂F₃N₇O₃

Base Information

• Chemical Name: C₂₈H₂₆Cl₂F₃N₇O₃
• CAS No.: 1431142-74-3
• Molecular Formula: C₂₈H₂₆Cl₂F₃N₇O₃
• Molecular Weight: 636.461
• Mol file: 1431142-74-3.mol

Synonyms:

Chemical Property of C₂₈H₂₆Cl₂F₃N₇O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₆Cl₂F₃N₇O₃

There total 5 articles about C₂₈H₂₆Cl₂F₃N₇O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6-ethoxy-pyridine (42144-78-5) → C28H26Cl2F3N7O3 (1431142-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 72 h / 55 °C

2: acetic acid / 2 h / 60 °C

With hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1016/j.bmcl.2013.01.064

Reference yield:

C20H18Cl2F3N3O4 → C28H26Cl2F3N7O3 (1431142-74-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine; ammonium chloride / dichloromethane

2: 20 °C

3: acetic acid / 2 h / 60 °C

With ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2013.01.064

Reference yield:

C21H20Cl2F3N3O4 (1431138-78-1) → C28H26Cl2F3N7O3 (1431142-74-3)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium hydroxide / tetrahydrofuran

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine; ammonium chloride / dichloromethane

3: 20 °C

4: acetic acid / 2 h / 60 °C

With ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2013.01.064

upstream raw materials:

6-ethoxy-2-hydrazinopyridine

2-chloro-6-ethoxy-pyridine

C₂₀H₁₉Cl₂F₃N₄O₃

C₂₁H₂₀Cl₂F₃N₃O₄

Downstream raw materials:

C₂₃H₁₈Cl₂F₃N₇O