42144-78-5

Basic information

• Product Name: 2-CHLORO-6-ETHOXYPYRIDINE
• Synonyms: 2-CHLORO-6-ETHOXYPYRIDINE;2-CHLORO-6-ETHOXYPYRIDINE, 98%%;6-Chloro-2-ethoxypyridine;Pyridine, 2-chloro-6-ethoxy-
• CAS NO: 42144-78-5
• Molecular Formula: C₇H₈ClNO
• Molecular Weight: 157.6
• EINECS: 255-681-9
• Product Categories: Chloropyridines;Halopyridines
• Mol File: 42144-78-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 207.9 °C at 760 mmHg
• Flash Point: 79.6 °C
• Appearance: /
• Density: 1.17
• Vapor Pressure: 0.316mmHg at 25°C
• Refractive Index: 1.5190
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.54±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-6-ETHOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-ETHOXYPYRIDINE(42144-78-5)
• EPA Substance Registry System: 2-CHLORO-6-ETHOXYPYRIDINE(42144-78-5)

Safety Data

• Statements: 20/21/22
• Safety Statements: 22-36/37
• Hazardous Substances Data: 42144-78-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-6-ethoxypyridine is a chemical compound with the molecular formula C7H8ClNO, and it is commonly used in the pharmaceutical and agrochemical industries. It is a pale yellow liquid with a mild, sweet odor, and it is primarily used as an intermediate in the synthesis of various pharmaceutical and agricultural products. It is also utilized in the production of herbicides, fungicides, and insecticides. Additionally, 2-Chloro-6-ethoxypyridine has been found to possess antimicrobial and antifungal properties, making it a versatile and valuable compound in the field of chemical research and development. However, it should be handled with caution as it is considered to be a hazardous substance and may cause skin and eye irritation upon contact.

InChI:InChI=1/C7H8ClNO/c1-2-10-7-5-3-4-6(8)9-7/h3-5H,2H2,1H3

Upstream product

• 2402-78-0 2,6-dichloropyridine 
• 141-52-6 sodium ethanolate 
• 64-17-5 ethanol 
• 87512-28-5 2-chloro-6-methylsulfinyl pyridine 
• 87512-29-6 2-chloro-6-(methylsulfonyl)pyridine 
• 77145-64-3 2-chloro-6-methylsulphenylpyridine 

Downstream Products

• 2402-78-0 2,6-dichloropyridine 
• 1246765-45-6 methyl 6-chloro-2-ethoxynicotinate 
• 1427301-13-0 C₂₃H₁₈Cl₂F₃N₇O 
• 1431142-74-3 C₂₈H₂₆Cl₂F₃N₇O₃ 
• 108122-25-4 1-(6-ethoxy-pyridin-2-yl)-piperazine 

Relevant articles and documents

Synthesis method and aftertreatment process of 6-chloro-2-hydrocarbyloxy pyridine

The invention relates to a synthesis method and an aftertreatment process of 6-chloro-2-hydrocarbyloxy pyridine. The synthesis method is characterized in that 2,6-dichloropyridine, alcohol and alkaliare used as starting raw materials; reaction is performed under the ordinary pressure and backflow state to generate 6-chloro-2-hydrocarbyloxy pyridine; the reaction conditions are mild; high conversion rate and high selectivity of the reaction are realized. The invention also relates to a treatment technology after reaction; the aftertreatment technology is simple and efficient; the circulation process is reasonably utilized for treating solid wastes and solvents; the environment protection problem in the aftertreatment process is creatively solved.

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS

A compound of formula I wherein: n is 1 or 2: p is 0 or 1; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; R6a and R6b are independently selected from H and Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.