Technology Process of Z-Pro-Gln-Gln-Phe
There total 10 articles about Z-Pro-Gln-Gln-Phe which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: H2 / Pd/C / methanol
2: 90 percent / dimethylformamide / -10 deg C, 2 h, RT
3: 94 percent / hydrazine hydrate / methanol / 40 deg C, 4 h, RT
4: 1.) 3.98 M HCl, isopentyl nitrite; 2.) TEA / 1.) DMF, dioxan, -30 deg C, 30 min; 2.) DMF, dioxan, -20 deg C, 2 h, pH=7.5-8, RT
5: 90 percent / HCOOH, anisole / 1 h / 80 °C
With
hydrogenchloride; formic acid; TEA; hydrogen; hydrazine hydrate; methoxybenzene; isopentyl nitrite;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-methylmorpholine / tetrahydrofuran / 0.02 h / -15 °C
2: N-methylmorpholine / tetrahydrofuran / -15 deg C, 30 min, RT
3: 98 percent / H2 / 5 percent Pd/C / methanol / 2 h / Ambient temperature
4: 1.) 3.98 M HCl, isopentyl nitrite; 2.) TEA / 1.) DMF, dioxan, -30 deg C, 30 min; 2.) DMF, dioxan, -20 deg C, 2 h, pH=7.5-8, RT
5: 90 percent / HCOOH, anisole / 1 h / 80 °C
With
4-methyl-morpholine; hydrogenchloride; formic acid; TEA; hydrogen; methoxybenzene; isopentyl nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-methylmorpholine / tetrahydrofuran / -15 deg C, 30 min, RT
2: 98 percent / H2 / 5 percent Pd/C / methanol / 2 h / Ambient temperature
3: 1.) 3.98 M HCl, isopentyl nitrite; 2.) TEA / 1.) DMF, dioxan, -30 deg C, 30 min; 2.) DMF, dioxan, -20 deg C, 2 h, pH=7.5-8, RT
4: 90 percent / HCOOH, anisole / 1 h / 80 °C
With
4-methyl-morpholine; hydrogenchloride; formic acid; TEA; hydrogen; methoxybenzene; isopentyl nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; methanol;