(pyrid-2-yl)methylamine dihydrochloride

Base Information

• Chemical Name: (pyrid-2-yl)methylamine dihydrochloride
• CAS No.: 50458-80-5
• Molecular Formula: C₆H₈N₂*2ClH
• Molecular Weight: 181.065
• Mol file: 50458-80-5.mol

Synonyms:

Chemical Property of (pyrid-2-yl)methylamine dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (pyrid-2-yl)methylamine dihydrochloride

There total 3 articles about (pyrid-2-yl)methylamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.5%

pyridine-2-carbaldehyde (1121-60-4) → (pyrid-2-yl)methylamine dihydrochloride (29968-84-1,50458-80-5,84359-11-5)

Guidance literature:

pyridine-2-carbaldehyde; With pyridoxal 5'-phosphate; ArRmut₁₁; isopropylamine; for 24h; Enzymatic reaction;

With hydrogenchloride; In diethyl ether; Reagent/catalyst;

DOI:10.1002/adsc.202100997

Reference yield: 69.0%

2-(nitromethyl)pyridine (3243-07-0) → (pyrid-2-yl)methylamine dihydrochloride (29968-84-1,50458-80-5,84359-11-5)

Guidance literature:

2-(nitromethyl)pyridine; With C₃₆H₅₆Cl₃CrN₂O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 60 ℃; for 24h; Inert atmosphere; Schlenk technique;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; at 20 ℃; chemoselective reaction;

DOI:10.1021/jacs.0c12318

Reference yield:

2-(Aminomethyl)pyridine (3731-51-9) → (pyrid-2-yl)methylamine dihydrochloride (29968-84-1,50458-80-5,84359-11-5)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 0.166667h;

DOI:10.1039/c9ra09294c

upstream raw materials:

2-(Aminomethyl)pyridine

2-(nitromethyl)pyridine

pyridine-2-carbaldehyde

Downstream raw materials:

N¹-<(pyrid-2-yl)methyl>-4-<(1,4,8,11-tetraazacyclotetradec-1-yl)methyl>benzamide pentahydrochloride