Technology Process of 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-α-L-erythro-pentofuranos-1-yl)-5-bromocytosine
There total 6 articles about 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-α-L-erythro-pentofuranos-1-yl)-5-bromocytosine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2,6-lutidine / CH2Cl2 / 36 h / Ambient temperature
2: 33 percent / Li(t-BuO)3AlH / tetrahydrofuran / 0.67 h / -50 °C
3: Et3N / CH2Cl2 / 2 h / Ambient temperature
4: 1.) HMDS, (NH4)2SO4, 2.) TMSOTf / 1.) 125 deg C, 4 h, 2.) dichloroethane, from 90 to 100 deg C, 10 h
With
2,6-dimethylpyridine; ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; lithium tri-t-butoxyaluminum hydride; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm970275y
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2,6-lutidine / CH2Cl2 / 36 h / Ambient temperature
2: 33 percent / Li(t-BuO)3AlH / tetrahydrofuran / 0.67 h / -50 °C
3: Et3N / CH2Cl2 / 2 h / Ambient temperature
4: 1.) HMDS, (NH4)2SO4, 2.) TMSOTf / 1.) 125 deg C, 4 h, 2.) dichloroethane, from 90 to 100 deg C, 10 h
With
2,6-dimethylpyridine; ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; lithium tri-t-butoxyaluminum hydride; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm970275y
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2 / 2 h / Ambient temperature
2: 1.) HMDS, (NH4)2SO4, 2.) TMSOTf / 1.) 125 deg C, 4 h, 2.) dichloroethane, from 90 to 100 deg C, 10 h
With
ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane;
In
dichloromethane;
DOI:10.1021/jm970275y