(R)-MTPA

Base Information

Chemical Name:(R)-MTPA
CAS No.:1508298-47-2
Molecular Formula:C₁₉H₂₄F₃NO₄
Molecular Weight:387.399
Hs Code.:

Synonyms:

Suppliers and Price of (R)-MTPA

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-MTPA

Chemical Property:

Purity/Quality:

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Technology Process of (R)-MTPA

There total 2 articles about (R)-MTPA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20445-31-2
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

: 277759-54-3,199588-89-1
tert-butyl α-allylglycinate

: 1508298-47-2
(R)-MTPA

: 1508298-48-3
(R)-MTPA

Guidance literature:: R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.75h; Inert atmosphere;

tert-butyl α-allylglycinate; With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/ol4028557

Reference yield:

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 1508298-47-2
(R)-MTPA

: 1508298-48-3
(R)-MTPA

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide; tetrabutyl-ammonium chloride / water; toluene / 20 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

With oxalyl dichloride; tetrabutyl-ammonium chloride; potassium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol4028557