C₂₉H₃₀F₂N₂O₂

Base Information

• Chemical Name: C₂₉H₃₀F₂N₂O₂
• CAS No.: 1366038-33-6
• Molecular Formula: C₂₉H₃₀F₂N₂O₂
• Molecular Weight: 476.566
• Mol file: 1366038-33-6.mol

Synonyms:

Chemical Property of C₂₉H₃₀F₂N₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₃₀F₂N₂O₂

There total 16 articles about C₂₉H₃₀F₂N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(hydroxymethyl)phenylboronic acid (87199-14-2) → C29H30F2N2O2 (1366038-33-6)

Guidance literature:

Multi-step reaction with 12 steps

1: bis(triphenylphosphine)palladium dibromide; sodium carbonate / ethanol; toluene

2: 1H-imidazole / N,N-dimethyl-formamide

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis(di-tertbutylphosphino)ferrocene; sodium t-butanolate / tetrahydrofuran

4: magnesium; lithium chloride / tetrahydrofuran

5: water; pyridinium p-toluenesulfonate / acetone

6: lithium borohydride / tetrahydrofuran

7: tetrabutyl ammonium fluoride / tetrahydrofuran

8: triethylamine / dichloromethane

9: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

10: sodium tetrahydroborate; cobalt(II) chloride hexahydrate / methanol

11: N-ethyl-N,N-diisopropylamine / dichloromethane

12: hydrogenchloride / 1,4-dioxane; dichloromethane

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium borohydride; 1,1'-bis(di-tertbutylphosphino)ferrocene; bis(triphenylphosphine)palladium dibromide; cobalt(II) chloride hexahydrate; tetrabutyl ammonium fluoride; water; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; 1: Suzuki coupling / 3: Buchwald-Hartwig α-arylation;

DOI:10.1016/j.bmcl.2012.01.044

Reference yield:

(2-bromo-4,5-difluorophenyl)methanol (476620-55-0) → C29H30F2N2O2 (1366038-33-6)

Guidance literature:

Multi-step reaction with 11 steps

1: Dess-Martin periodane / dichloromethane

2: toluene-4-sulfonic acid / benzene

3: magnesium; lithium chloride / tetrahydrofuran

4: water; pyridinium p-toluenesulfonate / acetone

5: lithium borohydride / tetrahydrofuran

6: tetrabutyl ammonium fluoride / tetrahydrofuran

7: triethylamine / dichloromethane

8: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

9: sodium tetrahydroborate; cobalt(II) chloride hexahydrate / methanol

10: N-ethyl-N,N-diisopropylamine / dichloromethane

11: hydrogenchloride / 1,4-dioxane; dichloromethane

With hydrogenchloride; sodium tetrahydroborate; lithium borohydride; cobalt(II) chloride hexahydrate; tetrabutyl ammonium fluoride; water; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; Dess-Martin periodane; toluene-4-sulfonic acid; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; benzene; 1: Dess-Martin oxidation;

DOI:10.1016/j.bmcl.2012.01.044

Reference yield:

(4'-bromo-3'-methyl-2-biphenylyl)methanol (1307795-18-1) → C29H30F2N2O2 (1366038-33-6)

Guidance literature:

Multi-step reaction with 11 steps

1: 1H-imidazole / N,N-dimethyl-formamide

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis(di-tertbutylphosphino)ferrocene; sodium t-butanolate / tetrahydrofuran

3: magnesium; lithium chloride / tetrahydrofuran

4: water; pyridinium p-toluenesulfonate / acetone

5: lithium borohydride / tetrahydrofuran

6: tetrabutyl ammonium fluoride / tetrahydrofuran

7: triethylamine / dichloromethane

8: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

9: sodium tetrahydroborate; cobalt(II) chloride hexahydrate / methanol

10: N-ethyl-N,N-diisopropylamine / dichloromethane

11: hydrogenchloride / 1,4-dioxane; dichloromethane

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium borohydride; 1,1'-bis(di-tertbutylphosphino)ferrocene; cobalt(II) chloride hexahydrate; tetrabutyl ammonium fluoride; water; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; 2: Buchwald-Hartwig α-arylation;

DOI:10.1016/j.bmcl.2012.01.044

upstream raw materials:

(2-bromo-4,5-difluorophenyl)methanol

2-bromo-4,5-difluorobenzaldehyde

2-(2-bromo-4,5-difluorophenyl)-1,3-dioxolane

(4'-bromo-3'-methyl-2-biphenylyl)methanol

Refernces