N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Base Information

• Chemical Name: N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide
• CAS No.: 145498-68-6
• Molecular Formula: C₄₀H₃₈N₅O₆PS₃
• Molecular Weight: 811.943
• Mol file: 145498-68-6.mol

Synonyms:

Chemical Property of N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

There total 1 articles about N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(N,N-diisopropylamino)-1,3,2-dithiaphospholane (145498-60-8) + N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (64325-78-6) → N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ5-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide (145498-68-6)

Guidance literature:

With 1H-tetrazole; sulfur; Yield given. Multistep reaction; 1.) CH₂Cl₂;

DOI:10.1016/S0040-4039(00)60831-6

Reference yield:

N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ5-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide (145498-68-6) + 3-Hydroxypropionitrile (109-78-4) → C41H38N6O7PS2(1-)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 0.25h; Yield given; Ambient temperature;

DOI:10.1021/jo961801g

upstream raw materials:

2-(N,N-diisopropylamino)-1,3,2-dithiaphospholane

N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine