Ethyl 4-chloroquinoline-7-carboxylate

Base Information

Chemical Name:Ethyl 4-chloroquinoline-7-carboxylate
CAS No.:282101-16-0
Molecular Formula:C₁₂H₁₀ClNO₂
Molecular Weight:235.67
Hs Code.:
DSSTox Substance ID:DTXSID00708110
Wikidata:Q82642202
Mol file:282101-16-0.mol

Synonyms:Ethyl 4-chloroquinoline-7-carboxylate;282101-16-0;Ethyl4-chloroquinoline-7-carboxylate;SCHEMBL6488275;DTXSID00708110;JWANQGUWFXQBGZ-UHFFFAOYSA-N;AKOS016002640;SB71755;AS-63135;CS-0040757;A876763

Suppliers and Price of Ethyl 4-chloroquinoline-7-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl4-chloroquinoline-7-carboxylate 97%
1g
$ 297.00

Chemenu
ethyl4-chloroquinoline-7-carboxylate 97%
1g
$ 280.00

Chemenu
ethyl4-chloroquinoline-7-carboxylate 97%
5g
$ 840.00

American Custom Chemicals Corporation
ETHYL-4-CHLOROQUINOLINE-7-CARBOXYLATE 95.00%
5MG
$ 497.79

Alichem
Ethyl4-chloroquinoline-7-carboxylate
5g
$ 681.75

Alichem
Ethyl4-chloroquinoline-7-carboxylate
1g
$ 240.75

AK Scientific
Ethyl4-chloroquinoline-7-carboxylate
250mg
$ 116.00

Total 11 raw suppliers

Chemical Property of Ethyl 4-chloroquinoline-7-carboxylate

Chemical Property:

Boiling Point:346.7±22.0 °C(Predicted)
PKA:1.68±0.27(Predicted)
Density:1.286±0.06 g/cm3(Predicted)
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:235.0400063
Heavy Atom Count:16
Complexity:259

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-chloroquinoline-7-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=CC2=NC=CC(=C2C=C1)Cl

Technology Process of Ethyl 4-chloroquinoline-7-carboxylate

There total 3 articles about Ethyl 4-chloroquinoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 49713-58-8
4‐chloroquinoline‐7‐carboxylic acid

: 64-17-5
ethanol

: 282101-16-0
ethyl 4-chloroquinoline-7-carboxylate

Guidance literature:: 4‐chloroquinoline‐7‐carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 16h;

ethanol; at 20 ℃; for 0.0833333h;

Reference yield: 55.0%

: 282101-16-0
ethyl 4-chloroquinoline-7-carboxylate

Guidance literature:: With trichlorophosphate; for 1h; Reflux;

Reference yield:

: 346-55-4
4-chloro-7-trifluoromethyl quinoline

: 282101-16-0
ethyl 4-chloroquinoline-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 4 h / 200 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran; dichloromethane / 16 h / 20 °C

2.2: 0.08 h / 20 °C

With oxalyl dichloride; sulfuric acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;