C₃₇H₄₇F₃N₄O₃

Base Information

• Chemical Name: C₃₇H₄₇F₃N₄O₃
• CAS No.: 1609377-74-3
• Molecular Formula: C₃₇H₄₇F₃N₄O₃
• Molecular Weight: 652.8
• Mol file: 1609377-74-3.mol

Synonyms:

Chemical Property of C₃₇H₄₇F₃N₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₄₇F₃N₄O₃

There total 5 articles about C₃₇H₄₇F₃N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-diamino-4-fluoro-N,N-dioctyl-benzamide (869203-27-0) + C14H8ClF2NO2 → C37H47F3N4O3 (1609377-74-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.201304161

Reference yield:

2-fluoroisophthalic acid monomethyl ester (914301-44-3) → C37H47F3N4O3 (1609377-74-3)

Guidance literature:

Multi-step reaction with 5 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3: lithium hydroxide monohydrate; water / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

4: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; lithium hydroxide monohydrate; water; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1002/chem.201304161

Reference yield:

2-fluoro-3-methoxycarbonylbenzoic acid chloride (869203-36-1) → C37H47F3N4O3 (1609377-74-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2: lithium hydroxide monohydrate; water / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; lithium hydroxide monohydrate; water; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1002/chem.201304161

upstream raw materials:

2-fluoroisophthalic acid monomethyl ester

2-fluoro-3-methoxycarbonylbenzoic acid chloride

C₁₅H₁₁F₂NO₃

C₁₄H₉F₂NO₃

Downstream raw materials:

C₄₄H₅₀F₃N₇O₄