3-(pyridin-2-yl)-1,2,4-thiadiazol-5-amine

Base Information

• Chemical Name: 3-(pyridin-2-yl)-1,2,4-thiadiazol-5-amine
• CAS No.: 138588-22-4
• Molecular Formula: C7H6N4S
• Molecular Weight: 178.217
• Hs Code.: 2934999090
• Mol file: 138588-22-4.mol

Synonyms:3-pyridin-2-yl-1,2,4-thiadiazol-5-amine;

Chemical Property of 3-(pyridin-2-yl)-1,2,4-thiadiazol-5-amine

Chemical Property:

• Vapor Pressure: 1.53E-06mmHg at 25°C
• Boiling Point: 397.9oC at 760 mmHg
• Flash Point: 194.5oC
• PSA: 92.93000
• Density: 1.412g/cm3
• LogP: 1.76350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

3-(Pyridin-2-yl)-1,2,4-thiadiazol-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(Pyridin-2-yl)-1,2,4-thiadiazol-5-amine a useful reactant for the preparation of five-?membered heterocyclic amine derivatives for the use of inflammation inhibitor.

Technology Process of 3-(pyridin-2-yl)-1,2,4-thiadiazol-5-amine

There total 1 articles about 3-(pyridin-2-yl)-1,2,4-thiadiazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(5-chloro-1,2,4-thiadiazol-3-yl)pyridine (887623-91-8) → 3-pyridin-2-yl-[1,2,4]thiadiazol-5-ylamine (138588-22-4)

Guidance literature:

With ammonia; In ethanol; at 70 ℃;

Reference yield: 60.0%

3-pyridin-2-yl-[1,2,4]thiadiazol-5-ylamine (138588-22-4) + para-chlorobenzoic acid (74-11-3) → 4-chloro-N-[3-(2-pyridyl)-1,2,4-thiadiazol-5-yl]benzamide

Guidance literature:

With N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridine-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield: 52.0%

3-pyridin-2-yl-[1,2,4]thiadiazol-5-ylamine (138588-22-4) + 4-Methoxyphenyl isocyanate (5416-93-3) → 1-(4-methoxyphenyl)-3-[3-(2-pyridyl)-1,2,4-thiadiazol-5-yl]urea

Guidance literature:

In tetrahydrofuran; at 50 ℃;

upstream raw materials:

2-(5-chloro-1,2,4-thiadiazol-3-yl)pyridine

Refernces