C₃₆H₄₂N₄O₈S

Base Information

• Chemical Name: C₃₆H₄₂N₄O₈S
• CAS No.: 1357450-98-6
• Molecular Formula: C₃₆H₄₂N₄O₈S
• Molecular Weight: 690.817
• Mol file: 1357450-98-6.mol

Synonyms:

Chemical Property of C₃₆H₄₂N₄O₈S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₄₂N₄O₈S

There total 5 articles about C₃₆H₄₂N₄O₈S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-tert-butoxycarbonylamino-4-(4-cyano-benzylcarbamoyl)-butyric acid benzyl ester (1221593-80-1) → C36H42N4O8S (1357450-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 1 h / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / pH 8 - 9

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm2011996

Reference yield:

Boc-Glu(OBzl)-OH (13574-13-5) → C36H42N4O8S (1357450-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / N,N-dimethyl-formamide / 0.17 h / -20 - -15 °C

1.2: -20 - 20 °C

2.1: dichloromethane / 1 h / 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / pH 8 - 9

With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm2011996

Reference yield:

4-cyanobenzylamine hydrochloride (15996-76-6) → C36H42N4O8S (1357450-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / N,N-dimethyl-formamide / 0.17 h / -20 - -15 °C

1.2: -20 - 20 °C

2.1: dichloromethane / 1 h / 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / pH 8 - 9

With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm2011996

upstream raw materials:

(S)-4-tert-butoxycarbonylamino-4-(4-cyano-benzylcarbamoyl)-butyric acid benzyl ester

Boc-Glu(OBzl)-OH

4-cyanobenzylamine hydrochloride

(R)-2-amino-5-(tert-butoxy)-5-oxopentanoic acid

Downstream raw materials:

benzylsulfonyl-D-Glu-Glu-4-cyanobenzylamide

C₃₃H₃₆N₆O₆S

C₃₃H₃₉N₇O₇S

C₂HF₃O₂*C₃₃H₃₉N₇O₆S