3-(MethoxyMethyl)-pyrrolidine HCl

Base Information

• Chemical Name: 3-(MethoxyMethyl)-pyrrolidine HCl
• CAS No.: 1185303-79-0
• Molecular Formula: C₆H₁₃NO*ClH
• Molecular Weight: 151.636
• Hs Code.: 2933998090
• Mol file: 1185303-79-0.mol

Synonyms:

Chemical Property of 3-(MethoxyMethyl)-pyrrolidine HCl

Chemical Property:

• Vapor Pressure: 5.73mmHg at 25°C

Purity/Quality:

99%min. ^*data from raw suppliers

3-(Methoxymethyl)pyrrolidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(MethoxyMethyl)-pyrrolidine HCl

There total 2 articles about 3-(MethoxyMethyl)-pyrrolidine HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-tert-butyl 3-(methoxymethyl)pyrrolidine-1-carboxylate (146257-05-8) → (R)-3-(methoxymethyl)pyrrolidine hydrochloride (1185303-79-0)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃;

DOI:10.1021/acsmedchemlett.8b00414

Reference yield:

tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate (138108-72-2) → (R)-3-(methoxymethyl)pyrrolidine hydrochloride (1185303-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / water / 20 °C

With hydrogenchloride; sodium hydride; In tetrahydrofuran; water; mineral oil;

DOI:10.1021/acsmedchemlett.8b00414

Reference yield:

{2-oxo-5-[4-(trifluoromethoxy)phenyl]-1,3-benzoxazol-3(2H)-yl}acetic acid + 3-(methoxymethyl)pyrrolidine hydrochloride (1185303-79-0) → C22H21F3N2O5 + C22H21F3N2O5

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 2h;

upstream raw materials:

(R)-tert-butyl 3-(methoxymethyl)pyrrolidine-1-carboxylate

tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate

Refernces