C₃₇H₄₁FN₂O₅

Base Information

• Chemical Name: C₃₇H₄₁FN₂O₅
• CAS No.: 1374037-23-6
• Molecular Formula: C₃₇H₄₁FN₂O₅
• Molecular Weight: 612.741
• Mol file: 1374037-23-6.mol

Synonyms:

Chemical Property of C₃₇H₄₁FN₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₄₁FN₂O₅

There total 3 articles about C₃₇H₄₁FN₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

N,N-bis-(tert-butoxycarbonyl)-3-[1-(3-ethynyl-benzoyl)-piperidin-4-yl]-benzylamine (375853-73-9) + 1-Fluoro-2-iodobenzene (348-52-7) → C37H41FN2O5 (1374037-23-6) + C62H74N4O10 (1374037-22-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 22h;

DOI:10.1016/j.bmcl.2012.01.021

Reference yield:

4-{3-[N,N-bis-(tert-butoxycarbonyl)aminomethyl]-phenyl}-piperidine (375853-65-9) → C37H41FN2O5 (1374037-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 22 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; 2: Sonogashira coupling;

DOI:10.1016/j.bmcl.2012.01.021

Reference yield:

4-{3-[N,N-bis-(tert-butoxycarbonyl)aminomethyl]-phenyl}-piperidine (375853-65-9) + 3-ethynylbenzoic acid (10601-99-7) → C37H41FN2O5 (1374037-23-6) + C62H74N4O10 (1374037-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 22 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; 2: Sonogashira coupling;

DOI:10.1016/j.bmcl.2012.01.021

upstream raw materials:

4-{3-[N,N-bis-(tert-butoxycarbonyl)aminomethyl]-phenyl}-piperidine

3-ethynylbenzoic acid

N,N-bis-(tert-butoxycarbonyl)-3-[1-(3-ethynyl-benzoyl)-piperidin-4-yl]-benzylamine

1-Fluoro-2-iodobenzene