Technology Process of 1,2,3,4-tetrahydro-5,8-dihydroxy-2-methyl-1-(3-phenoxybenzyl)isoquinoline hydrobromide
There total 5 articles about 1,2,3,4-tetrahydro-5,8-dihydroxy-2-methyl-1-(3-phenoxybenzyl)isoquinoline hydrobromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen bromide;
reflux, 4 h, 2 deg C, 2 h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 62.3 percent / toluene; light petroleum / reflux, 12-20 h, 55-60 deg C -> 2 deg C, several h
2: 1.) phosphoryl trichloride, 2.) 60percent perchloric acid / 1.) CHCl3, reflux, 5-12 h, water, 60 deg C, 30 min, 2.) 2 deg C, several h
3: 1.) sodium borohydride, 2.) HCl / 1.) ethanol, 60 min
4: 97 percent / 48percent HBr / reflux, 4 h, 2 deg C, 2 h
With
hydrogenchloride; sodium tetrahydroborate; perchloric acid; hydrogen bromide; trichlorophosphate;
In
toluene; Petroleum ether;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 62.3 percent / toluene; light petroleum / reflux, 12-20 h, 55-60 deg C -> 2 deg C, several h
2: 1.) phosphoryl trichloride, 2.) 60percent perchloric acid / 1.) CHCl3, reflux, 5-12 h, water, 60 deg C, 30 min, 2.) 2 deg C, several h
3: 1.) sodium borohydride, 2.) HCl / 1.) ethanol, 60 min
4: 97 percent / 48percent HBr / reflux, 4 h, 2 deg C, 2 h
With
hydrogenchloride; sodium tetrahydroborate; perchloric acid; hydrogen bromide; trichlorophosphate;
In
toluene; Petroleum ether;
