Technology Process of N-(3-[3-[2-Fluoro-3-(trifluoromethyl)phenyl]-8-methoxy-4-oxocinnolin-1(4H)-yl]propyl)methanesulphonamide
There total 7 articles about N-(3-[3-[2-Fluoro-3-(trifluoromethyl)phenyl]-8-methoxy-4-oxocinnolin-1(4H)-yl]propyl)methanesulphonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogenchloride; sodium nitrite / water / 0 - 20 °C
2.1: potassium ethoxide; acetic acid / Reflux
2.2: 1.5 h / Reflux
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 6 h / 0 - 75 °C
4.1: hydrazine hydrate / methanol / 3 h / 65 °C
5.1: triethylamine / dichloromethane / 20 °C
6.1: sodium carbonate / toluene; methanol / 75 °C / Inert atmosphere
With
hydrogenchloride; potassium ethoxide; sodium hydride; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; sodium nitrite;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 6 h / 0 - 75 °C
2: hydrazine hydrate / methanol / 3 h / 65 °C
3: triethylamine / dichloromethane / 20 °C
4: sodium carbonate / toluene; methanol / 75 °C / Inert atmosphere
With
sodium hydride; sodium carbonate; hydrazine hydrate; triethylamine;
In
methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C
2.1: methylmagnesium bromide / tetrahydrofuran / -40 - 20 °C
3.1: trifluoroacetic acid / dichloromethane / 20 °C
4.1: hydrogenchloride; sodium nitrite / water / 0 - 20 °C
5.1: potassium ethoxide; acetic acid / Reflux
5.2: 1.5 h / Reflux
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 6 h / 0 - 75 °C
7.1: hydrazine hydrate / methanol / 3 h / 65 °C
8.1: triethylamine / dichloromethane / 20 °C
9.1: sodium carbonate / toluene; methanol / 75 °C / Inert atmosphere
With
hydrogenchloride; methylmagnesium bromide; potassium ethoxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic acid; sodium nitrite;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;
