C₂₇H₄₃ClN₄O₃

Base Information

Chemical Name:C₂₇H₄₃ClN₄O₃
CAS No.:1448902-85-9
Molecular Formula:C₂₇H₄₃ClN₄O₃
Molecular Weight:507.116
Hs Code.:

C<sub>27</sub>H<sub>43</sub>ClN<sub>4</sub>O<sub>3</sub>

Synonyms:

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Chemical Property of C₂₇H₄₃ClN₄O₃

Chemical Property:

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Technology Process of C₂₇H₄₃ClN₄O₃

There total 7 articles about C₂₇H₄₃ClN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448902-63-3
(3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-[(1R)-2-hydroxy-1-isobutyl-3-methylbutyl]-1-(2-nitrophenyl)sulfonylpiperidine-3-carboxamide

: 1448902-85-9
C₂₇H₄₃ClN₄O₃

Guidance literature:: With caesium carbonate; thiophenol; In acetonitrile; at 20 ℃; for 1.5h;
DOI:10.1016/j.bmcl.2012.09.103

Reference yield:

: 2,4-dioxo-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylic acid tert-butyl ester

: 1448902-85-9
C₂₇H₄₃ClN₄O₃

Guidance literature:: Multi-step reaction with 16 steps

1: C₂₈H₂₇F₆N₃O₃S / tetrahydrofuran / 24 h / -20 °C

2: diphenylphosphoranyl azide; triethylamine / toluene / 15 h / 90 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: triethylamine / dichloromethane / 1 h / 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; morpholine / tetrahydrofuran / 1 h / 20 °C

6: dichloromethane / 2 h / 20 °C

7: N-chloro-succinimide / dichloromethane / 2 h / 20 °C

8: 18 h / 60 °C

9: hydrogenchloride / dichloromethane; water / 4 h / 40 °C

10: thionyl chloride / 1 h / 20 °C

11: acetic acid / toluene / 2 h / 110 °C

12: sodium cyanoborohydride / 6 h / 20 °C

13: triethylamine / dichloromethane / 5 h / 0 - 40 °C

14: sodium hydroxide; water / methanol / 0.5 h / 50 °C

15: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

16: thiophenol; caesium carbonate / acetonitrile / 1.5 h / 20 °C

With morpholine; hydrogenchloride; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; C₂₈H₂₇F₆N₃O₃S; diphenylphosphoranyl azide; water; sodium cyanoborohydride; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 2: |Curtius Rearrangement;
DOI:10.1016/j.bmcl.2012.09.103

Reference yield:

: C₁₇H₂₂ClN₃O₆S

: 1448902-85-9
C₂₇H₄₃ClN₄O₃

Guidance literature:: Multi-step reaction with 9 steps

1: 18 h / 60 °C

2: hydrogenchloride / dichloromethane; water / 4 h / 40 °C

3: thionyl chloride / 1 h / 20 °C

4: acetic acid / toluene / 2 h / 110 °C

5: sodium cyanoborohydride / 6 h / 20 °C

6: triethylamine / dichloromethane / 5 h / 0 - 40 °C

7: sodium hydroxide; water / methanol / 0.5 h / 50 °C

8: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

9: thiophenol; caesium carbonate / acetonitrile / 1.5 h / 20 °C

With hydrogenchloride; thionyl chloride; water; sodium cyanoborohydride; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.09.103