6,7-dimethoxy-2-(4-nitrobenzoyl)-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinolinecarboxylic acid N-methylamide

Base Information

• Chemical Name: 6,7-dimethoxy-2-(4-nitrobenzoyl)-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinolinecarboxylic acid N-methylamide
• CAS No.: 1219371-91-1
• Molecular Formula: C₂₄H₂₇N₃O₆
• Molecular Weight: 453.495
• Mol file: 1219371-91-1.mol

Synonyms:

Chemical Property of 6,7-dimethoxy-2-(4-nitrobenzoyl)-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinolinecarboxylic acid N-methylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 6,7-dimethoxy-2-(4-nitrobenzoyl)-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinolinecarboxylic acid N-methylamide

There total 1 articles about 6,7-dimethoxy-2-(4-nitrobenzoyl)-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinolinecarboxylic acid N-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

6,7-dimethoxy-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid N-methylamide (329965-88-0) + 4-nitro-benzoyl chloride (122-04-3) → 6,7-dimethoxy-2-(4-nitrobenzoyl)-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinolinecarboxylic acid N-methylamide (1219371-91-1)

Guidance literature:

With pyridine; In benzene; Reflux;

DOI:10.1007/s10593-009-0385-5

upstream raw materials:

6,7-dimethoxy-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid N-methylamide

4-nitro-benzoyl chloride