4-Heptenamide, 7-[3-[2-(2,5-dimethoxy-3-nitrophenyl)-2-methoxy-1-methylethyl]-4-oxo-2- oxetanyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N,7-dimethoxy-N,2,4,6 -tetramethyl-

Base Information

Chemical Name:4-Heptenamide, 7-[3-[2-(2,5-dimethoxy-3-nitrophenyl)-2-methoxy-1-methylethyl]-4-oxo-2- oxetanyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N,7-dimethoxy-N,2,4,6 -tetramethyl-
CAS No.:138694-24-3
Molecular Formula:C34H56N2O11Si
Molecular Weight:696.911
Hs Code.:

4-Heptenamide,
7-[3-[2-(2,5-dimethoxy-3-nitrophenyl)-2-methoxy-1-methylethyl]-4-oxo-2-
oxetanyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N,7-dimethoxy-N,2,4,6
-tetramethyl-

Synonyms:

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Chemical Property of 4-Heptenamide, 7-[3-[2-(2,5-dimethoxy-3-nitrophenyl)-2-methoxy-1-methylethyl]-4-oxo-2- oxetanyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N,7-dimethoxy-N,2,4,6 -tetramethyl-

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Technology Process of 4-Heptenamide, 7-[3-[2-(2,5-dimethoxy-3-nitrophenyl)-2-methoxy-1-methylethyl]-4-oxo-2- oxetanyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N,7-dimethoxy-N,2,4,6 -tetramethyl-

There total 18 articles about 4-Heptenamide, 7-[3-[2-(2,5-dimethoxy-3-nitrophenyl)-2-methoxy-1-methylethyl]-4-oxo-2- oxetanyl]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N,7-dimethoxy-N,2,4,6 -tetramethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 138721-95-6
(2R,3R,4E,6S,7R,10S,11R)-3-(tert-Butyldimethylsilyloxy)-11-(2,5-dimethoxy-3-nitrophenyl)-8-hydroxy-N,7,11-trimethoxy-N,2,4,6,10-pentamethyl-9-<(2-thioxo-3-thiazolidinyl)carbonyl>-4-undecenamide

: 138694-24-3
3-<(1S,2R)-2-(2,5-Dimethoxy-3-nitrophenyl)-2-methoxy-1-methylethanyl>-4-<(1R,2S,3E,5R,6R)-5-(tert-butyldimethylsiloxy)-N,1-dimethoxy-N,2,4,6-tetramethylhept-3-en-7-amido>oxetan-2-one

Guidance literature:: With potassium carbonate; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/jo00054a035

Reference yield:

: 138694-19-6
(2R,3R,4E)-3-Methoxy-2-methyl-5-phenyl-4-pentenal

: 138694-24-3
3-<(1S,2R)-2-(2,5-Dimethoxy-3-nitrophenyl)-2-methoxy-1-methylethanyl>-4-<(1R,2S,3E,5R,6R)-5-(tert-butyldimethylsiloxy)-N,1-dimethoxy-N,2,4,6-tetramethylhept-3-en-7-amido>oxetan-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: 78 percent / toluene / 9 h / Heating

2: 90 percent / DIBAL-H / CH₂Cl₂; toluene / 1 h / -78 °C

3: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, 20 min, -60 deg C, 2) 2h 15 min, -60 deg C

5: 1) Me₃Al / 1) CH₂Cl₂, toluene, 30 min, r.t., 2) CH₂Cl₂, 18 h, -20 deg C

6: 91 percent / imidazole / dimethylformamide / 18 h / Ambient temperature

7: 1) OsO₄, N-methylmorpholine oxide, 2) NaIO₄, NaHCO₃ / 1) t-BuOH, water, THF, 3 h, r.t., 2) water, 45 min

8: 1) TiCl₄, Et₃N / 1) CH₂Cl₂, 1 h, 0 deg C, 2) CH₂Cl₂, 0 deg C, 3.3 h

9: 88 percent / K₂CO₃ / tetrahydrofuran / 2 h / Heating

With 1H-imidazole; sodium periodate; osmium(VIII) oxide; oxalyl dichloride; trimethylaluminum; titanium tetrachloride; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00054a035

Reference yield:

: 138694-13-0
(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid

: 138694-24-3
3-<(1S,2R)-2-(2,5-Dimethoxy-3-nitrophenyl)-2-methoxy-1-methylethanyl>-4-<(1R,2S,3E,5R,6R)-5-(tert-butyldimethylsiloxy)-N,1-dimethoxy-N,2,4,6-tetramethylhept-3-en-7-amido>oxetan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: (COCl)2, DMF / CH₂Cl₂ / 16 h / Ambient temperature

2: CH₂Cl₂; diethyl ether / 0.5 h / 0 °C

3: 87 percent / AgNO₃, H₂O / tetrahydrofuran / 23 h / 25 °C

4: 84 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide*HCl, DMAP / CH₂Cl₂ / 24 h

5: 1) TiCl₄, Et₃N / 1) CH₂Cl₂, 1 h, 0 deg C, 2) CH₂Cl₂, 0 deg C, 3.3 h

6: 88 percent / K₂CO₃ / tetrahydrofuran / 2 h / Heating

With dmap; oxalyl dichloride; water; titanium tetrachloride; potassium carbonate; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00054a035