(E)-di-tert-butyl (2-(1-(hydroxymethyl)-3-(3-(3-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl) phosphate

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Chemical Name:(E)-di-tert-butyl (2-(1-(hydroxymethyl)-3-(3-(3-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl) phosphate
CAS No.:1363481-19-9
Molecular Formula:C₃₃H₄₂N₃O₁₁PS
Molecular Weight:719.75
Hs Code.:

(E)-di-tert-butyl (2-(1-(hydroxymethyl)-3-(3-(3-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl) phosphate

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Chemical Property of (E)-di-tert-butyl (2-(1-(hydroxymethyl)-3-(3-(3-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl) phosphate

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Technology Process of (E)-di-tert-butyl (2-(1-(hydroxymethyl)-3-(3-(3-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl) phosphate

There total 13 articles about (E)-di-tert-butyl (2-(1-(hydroxymethyl)-3-(3-(3-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl) phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 1363481-13-3
di-tert-butyl (2-(1-(Hydroxymethyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl) phosphate

: 1363481-19-9
(E)-di-tert-butyl (2-(1-(hydroxymethyl)-3-(3-(3-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl) phosphate

Guidance literature:: With toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; for 4h;
DOI:10.1021/jm201717y

Reference yield:

: 1214876-51-3
2,2,2-trifluoro-1-(1-(iodomethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl)ethan-1-one

: 1363481-19-9
(E)-di-tert-butyl (2-(1-(hydroxymethyl)-3-(3-(3-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl) phosphate

Guidance literature:: Multi-step reaction with 7 steps

1: 18-crown-6 ether / acetic acid / 120 h / 100 °C

2: chlorosulfonic acid / dichloromethane / -80 - 5 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / 3 h / -10 - 5 °C

4: sulfuric acid; potassium nitrate / 0.25 h / -12 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

6: water; caesium carbonate / methanol / 3 h / 0 - 20 °C

7: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 4 h

With chlorosulfonic acid; oxalyl dichloride; 18-crown-6 ether; sulfuric acid; water; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl acetamide; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm201717y

Reference yield:

: 885226-91-5
1-(1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-2,2,2-trifluoroethanone

: 1363481-19-9
(E)-di-tert-butyl (2-(1-(hydroxymethyl)-3-(3-(3-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl) phosphate

Guidance literature:: Multi-step reaction with 8 steps

1: sodium iodide / butanone / 17 h / 85 °C

2: 18-crown-6 ether / acetic acid / 120 h / 100 °C

3: chlorosulfonic acid / dichloromethane / -80 - 5 °C

4: oxalyl dichloride / N,N-dimethyl-formamide / 3 h / -10 - 5 °C

5: sulfuric acid; potassium nitrate / 0.25 h / -12 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

7: water; caesium carbonate / methanol / 3 h / 0 - 20 °C

8: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 4 h

With chlorosulfonic acid; oxalyl dichloride; 18-crown-6 ether; sulfuric acid; water; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; N-ethyl-N,N-diisopropylamine; sodium iodide; In methanol; dichloromethane; N,N-dimethyl acetamide; acetic acid; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm201717y