3-[(2R,3R,4R,5R)-4-[(5-Chloro-quinolin-8-yloxy)-(2,6-dichloro-phenoxy)-phosphoryloxy]-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester

Base Information

Chemical Name:3-[(2R,3R,4R,5R)-4-[(5-Chloro-quinolin-8-yloxy)-(2,6-dichloro-phenoxy)-phosphoryloxy]-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester
CAS No.:124735-97-3
Molecular Formula:C₃₄H₃₅Cl₃N₃O₁₁PS
Molecular Weight:831.064
Hs Code.:

3-[(2R,3R,4R,5R)-4-[(5-Chloro-quinolin-8-yloxy)-(2,6-dichloro-phenoxy)-phosphoryloxy]-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester

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Chemical Property of 3-[(2R,3R,4R,5R)-4-[(5-Chloro-quinolin-8-yloxy)-(2,6-dichloro-phenoxy)-phosphoryloxy]-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester

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Technology Process of 3-[(2R,3R,4R,5R)-4-[(5-Chloro-quinolin-8-yloxy)-(2,6-dichloro-phenoxy)-phosphoryloxy]-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester

There total 5 articles about 3-[(2R,3R,4R,5R)-4-[(5-Chloro-quinolin-8-yloxy)-(2,6-dichloro-phenoxy)-phosphoryloxy]-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116113-47-4
C₅₅H₅₃Cl₃N₃O₁₃PS

: 124735-97-3
3-[(2R,3R,4R,5R)-4-[(5-Chloro-quinolin-8-yloxy)-(2,6-dichloro-phenoxy)-phosphoryloxy]-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester

Guidance literature:: With toluene-4-sulfonic acid; In methanol; dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1016/S0040-4039(00)96821-7

Reference yield:

: 93636-01-2
2,6-dichlorophenyl 5-chloro-8-quinolyl phosphorochloridate

: 124735-97-3
3-[(2R,3R,4R,5R)-4-[(5-Chloro-quinolin-8-yloxy)-(2,6-dichloro-phenoxy)-phosphoryloxy]-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: TsOH / methanol; CH₂Cl₂ / 0.17 h / 0 °C

With toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)96821-7

Reference yield:

: 114744-08-0
3-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester

: 124735-97-3
3-[(2R,3R,4R,5R)-4-[(5-Chloro-quinolin-8-yloxy)-(2,6-dichloro-phenoxy)-phosphoryloxy]-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: TsOH / methanol; CH₂Cl₂ / 0.17 h / 0 °C

With toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)96821-7