Technology Process of 3-(4-(5-aminopentyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
There total 8 articles about 3-(4-(5-aminopentyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl (5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)carbamate;
With
palladium on activated charcoal; hydrogen;
In
ethanol;
at 20 ℃;
for 2h;
under 760.051 Torr;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 0.5h;
DOI:10.1021/acs.jmedchem.8b00909
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 12 h / 80 °C
2: triethylamine / acetonitrile / 10 h / 60 °C
3: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 10 h / 70 °C / Inert atmosphere
4: palladium 10% on activated carbon; hydrogen / methanol / 20 °C
5: trifluoroacetic acid / dichloromethane / 0.5 h
With
bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; palladium 10% on activated carbon; hydrogen; triethylamine; trifluoroacetic acid; dibenzoyl peroxide;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile; benzene;
