tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(4-(trifluoromethyl)benzyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate

Base Information

Chemical Name:tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(4-(trifluoromethyl)benzyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate
CAS No.:1439362-26-1
Molecular Formula:C₄₇H₄₉F₃N₄O₂
Molecular Weight:758.927
Hs Code.:

tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(4-(trifluoromethyl)benzyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate

Synonyms:

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Chemical Property of tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(4-(trifluoromethyl)benzyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate

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Useful:

Technology Process of tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(4-(trifluoromethyl)benzyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate

There total 11 articles about tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(4-(trifluoromethyl)benzyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1021122-87-1
2-(1-(4-trifluoromethylphenylmethylamino)methyl)pyridine

: 1439362-14-7
tert-butyl 3-(((4'-(bromomethyl)biphenyl-4-yl)methyl)(naphthalen-1-ylmethyl)amino)propylcarbamate

: 1439362-26-1
tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(4-(trifluoromethyl)benzyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile;
DOI:10.1002/cmdc.201200390

Reference yield:

: 3731-51-9
2-(Aminomethyl)pyridine

: 1439362-26-1
tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(4-(trifluoromethyl)benzyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran

3: potassium carbonate; thiophenol / N,N-dimethyl-formamide

4: potassium iodide; potassium carbonate / acetonitrile

With potassium carbonate; thiophenol; triethylamine; triphenylphosphine; potassium iodide; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 2: |Mitsunobu Displacement;
DOI:10.1002/cmdc.201200390

Reference yield:

: 117507-66-1
N-(2-nitrobenzenesulfonyl)-2-(aminomethyl)pyridine

: 1439362-26-1
tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(4-(trifluoromethyl)benzyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran

2: potassium carbonate; thiophenol / N,N-dimethyl-formamide

3: potassium iodide; potassium carbonate / acetonitrile

With potassium carbonate; thiophenol; triphenylphosphine; potassium iodide; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1: |Mitsunobu Displacement;
DOI:10.1002/cmdc.201200390