1-(3-Chloro-4-methylbenzoyl)-4-piperidinone

Base Information

Chemical Name:1-(3-Chloro-4-methylbenzoyl)-4-piperidinone
CAS No.:223632-66-4
Molecular Formula:C₁₃H₁₄ClNO₂
Molecular Weight:251.713
Hs Code.:
DSSTox Substance ID:DTXSID701263270

Synonyms:SCHEMBL4546530;DTXSID701263270;AKOS012497420;1-(3-Chloro-4-methylbenzoyl)-4-piperidinone;223632-66-4

Suppliers and Price of 1-(3-Chloro-4-methylbenzoyl)-4-piperidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-Chloro-4-methylbenzoyl)-4-piperidinone

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:251.0713064
Heavy Atom Count:17
Complexity:309

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=C(C=C1)C(=O)N2CCC(=O)CC2)Cl

Technology Process of 1-(3-Chloro-4-methylbenzoyl)-4-piperidinone

There total 3 articles about 1-(3-Chloro-4-methylbenzoyl)-4-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3-chloro-4-methyl-phenyl)-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-methanone

: 223632-66-4
N-(3-chloro-4-methylbenzoyl)-piperidin-4-one

Guidance literature:: With formic acid; copper(II) sulfate; at 80 ℃; for 16h; Yield given;
DOI:10.1021/jm9806906

Reference yield:

: 21900-30-1
3-chloro-4-methyl-benzoyl chloride

: 223632-66-4
N-(3-chloro-4-methylbenzoyl)-piperidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: TEA / CHCl₃ / 17 h / Ambient temperature

2: 80 percent aq. formic acid, CuSO₄ / 16 h / 80 °C

With formic acid; TEA; copper(II) sulfate; In chloroform;
DOI:10.1021/jm9806906

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 223632-66-4
N-(3-chloro-4-methylbenzoyl)-piperidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: TEA / CHCl₃ / 17 h / Ambient temperature

2: 80 percent aq. formic acid, CuSO₄ / 16 h / 80 °C

With formic acid; TEA; copper(II) sulfate; In chloroform;
DOI:10.1021/jm9806906