(6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-2-yl)(4-methoxyphenyl)methanone

Base Information

Chemical Name:(6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-2-yl)(4-methoxyphenyl)methanone
CAS No.:1246523-59-0
Molecular Formula:C₄₆H₄₈BNO₈
Molecular Weight:753.7
Hs Code.:

(6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-2-yl)(4-methoxyphenyl)methanone

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Chemical Property of (6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-2-yl)(4-methoxyphenyl)methanone

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Technology Process of (6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-2-yl)(4-methoxyphenyl)methanone

There total 12 articles about (6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-2-yl)(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246523-48-7
(4-bromo-6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-1H-indol-2-yl)(4-methoxyphenyl)methanone

: 73183-34-3
bis(pinacol)diborane

: 1246523-59-0
(6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-2-yl)(4-methoxyphenyl)methanone

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; for 3h; Reflux;
DOI:10.1002/anie.201001966

Reference yield:

: 1246523-50-1
4-bromo-6-methoxy-3,7-bis-(4-methoxy-phenyl)-2,3-dihydro-1H-indole

: 1246523-59-0
(6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-2-yl)(4-methoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 1 h / 20 °C

2.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 2 h

3.1: zinc(II) chloride / diethyl ether / 0 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 3 h / Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; zinc(II) chloride; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1002/asia.201000544

Reference yield:

: 1246523-51-2
4-bromo-6-methoxy-3,7-bis-(4-methoxy-phenyl)-1H-indole

: 1246523-59-0
(6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-2-yl)(4-methoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 2 h

2.1: zinc(II) chloride / diethyl ether / 0 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 3 h / Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium hydroxide; zinc(II) chloride; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/asia.201000544