3-(tetrahydro-2H-pyran-2-yloxy)-12,13-epoxytrichothec-9-ene-4,15-diyl diacetate

Base Information

• Chemical Name: 3-(tetrahydro-2H-pyran-2-yloxy)-12,13-epoxytrichothec-9-ene-4,15-diyl diacetate
• CAS No.: 77620-40-7
• Molecular Formula: C₂₄H₃₄O₈
• Molecular Weight: 450.529
• Mol file: 77620-40-7.mol

Synonyms:

Chemical Property of 3-(tetrahydro-2H-pyran-2-yloxy)-12,13-epoxytrichothec-9-ene-4,15-diyl diacetate

Chemical Property:

• Vapor Pressure: 2E-11mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(tetrahydro-2H-pyran-2-yloxy)-12,13-epoxytrichothec-9-ene-4,15-diyl diacetate

There total 13 articles about 3-(tetrahydro-2H-pyran-2-yloxy)-12,13-epoxytrichothec-9-ene-4,15-diyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,4-dihydro-2H-pyran (110-87-2) + 4,15-diacetoxyscirpenol (2270-40-8,28776-47-8) → 12,13-epoxytrichothec-9-ene-3α,4β,15-triol 4β,15-diacetate 3α-tetrahydropyranyl acetal (77620-40-7)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; for 15h; Ambient temperature;

DOI:10.1002/hlca.19880710808

Reference yield: 72.0%

3,4-dihydro-2H-pyran (110-87-2) + anguidine (2270-40-8,106454-36-8,28776-47-8) → 4β,15-diacetoxy-3α-O-(2-tetrahydropyranyl)scirpene (77620-40-7,97372-95-7,97413-94-0,106454-35-7)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jm00347a018

Reference yield: 19.0%

N-Acetylimidazole (2466-76-4) + C20H30O6 (77620-41-8,97372-96-8,97413-89-3,106454-34-6) → C22H32O7 (97350-75-9,97350-77-1,121471-17-8) + C24H34O8 (77620-40-7,97372-95-7,97413-94-0,106454-35-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In benzene; for 6h; Ambient temperature;

DOI:10.1021/jo00217a046

upstream raw materials:

3,4-dihydro-2H-pyran

anguidine

anguidine

acetic anhydride

Downstream raw materials:

4-β-acetoxyscirpene-3α,15-diol

C₂₀H₃₀O₆

12,13-epoxy-3α-<(tetrahydro-2H-pyranyl)oxy>trichothec-9-ene-4β,15-diol

12,13-epoxy-4β-hydroxy-3α-<(tetrahydro-2H-pyranyl)oxy>trichothec-9-en-15-yl acetate