Technology Process of trans,trans-(5S)-5-<9'-(2,3-bis((dimethylthexylsilyl)oxy)cyclohexyl)-3'-nonenyl>-2,3-dihydrofuranone
There total 11 articles about trans,trans-(5S)-5-<9'-(2,3-bis((dimethylthexylsilyl)oxy)cyclohexyl)-3'-nonenyl>-2,3-dihydrofuranone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 85 percent / PPh3, CBr4 / acetonitrile / Ambient temperature
2: 70 percent / azobisisobutyronitryle / toluene / 30 h / Heating
3: 1. O3, 2.) Me2S / 1.) MeOH, CH2Cl2, -78 deg C, 2.) -78 deg C, 1 h
4: various solvent(s) / 40 h / Heating
With
dimethylsulfide; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; ozone; triphenylphosphine;
In
toluene; acetonitrile;
DOI:10.1021/jo00247a014
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 95 percent / Et3N, bis(trimethylsilyl)amine / tetrahydrofuran / Ambient temperature
3: 1.) BH3*Me2S, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, RT, 3 days 2.) 1 h
4: 84 percent / CBr4, PPh3 / acetonitrile / 1 h / 0 °C
5: 95 percent / lutidine / CH2Cl2 / 0 - 20 °C
6: acetonitrile / 72 h / Heating
7: various solvent(s) / 40 h / Heating
With
sodium hydroxide; carbon tetrabromide; dimethylsulfide borane complex; lutidine; dihydrogen peroxide; triethylamine; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo00247a014
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 98 percent / BH3*Me2S / tetrahydrofuran / 0 °C
2: 95 percent / Et3N, bis(trimethylsilyl)amine / tetrahydrofuran / Ambient temperature
4: 1.) BH3*Me2S, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, RT, 3 days 2.) 1 h
5: 84 percent / CBr4, PPh3 / acetonitrile / 1 h / 0 °C
6: 95 percent / lutidine / CH2Cl2 / 0 - 20 °C
7: acetonitrile / 72 h / Heating
8: various solvent(s) / 40 h / Heating
With
sodium hydroxide; carbon tetrabromide; dimethylsulfide borane complex; lutidine; dihydrogen peroxide; triethylamine; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo00247a014
