2-({3-[4-(2-Benzoylamino-2-methylcarbamoyl-ethyl)-imidazol-1-ylmethyl]-2-hydroxy-tetrahydro-furan-2-carbonyl}-amino)-3,4-dihydroxy-4-methyl-tetrahydro-furan-2-carboxylic acid amide

Base Information

• Chemical Name: 2-({3-[4-(2-Benzoylamino-2-methylcarbamoyl-ethyl)-imidazol-1-ylmethyl]-2-hydroxy-tetrahydro-furan-2-carbonyl}-amino)-3,4-dihydroxy-4-methyl-tetrahydro-furan-2-carboxylic acid amide
• CAS No.: 120546-81-8
• Molecular Formula: C₂₆H₃₄N₆O₉
• Molecular Weight: 574.591
• Mol file: 120546-81-8.mol

Synonyms:

Chemical Property of 2-({3-[4-(2-Benzoylamino-2-methylcarbamoyl-ethyl)-imidazol-1-ylmethyl]-2-hydroxy-tetrahydro-furan-2-carbonyl}-amino)-3,4-dihydroxy-4-methyl-tetrahydro-furan-2-carboxylic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-({3-[4-(2-Benzoylamino-2-methylcarbamoyl-ethyl)-imidazol-1-ylmethyl]-2-hydroxy-tetrahydro-furan-2-carbonyl}-amino)-3,4-dihydroxy-4-methyl-tetrahydro-furan-2-carboxylic acid amide

There total 2 articles about 2-({3-[4-(2-Benzoylamino-2-methylcarbamoyl-ethyl)-imidazol-1-ylmethyl]-2-hydroxy-tetrahydro-furan-2-carbonyl}-amino)-3,4-dihydroxy-4-methyl-tetrahydro-furan-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

(dl)-Nα-Benzoylhistidine methylamide (120546-75-0) + bicyclomycin (38129-37-2) → 2-({3-[4-(2-Benzoylamino-2-methylcarbamoyl-ethyl)-imidazol-1-ylmethyl]-2-hydroxy-tetrahydro-furan-2-carbonyl}-amino)-3,4-dihydroxy-4-methyl-tetrahydro-furan-2-carboxylic acid amide (120546-81-8)

Guidance literature:

In tetrahydrofuran; water; for 20h; Ambient temperature; pH = 9.90;

DOI:10.1021/ja00195a049

Reference yield:

N-α-Benzoylhistidine methyl ester (120546-89-6) → 2-({3-[4-(2-Benzoylamino-2-methylcarbamoyl-ethyl)-imidazol-1-ylmethyl]-2-hydroxy-tetrahydro-furan-2-carbonyl}-amino)-3,4-dihydroxy-4-methyl-tetrahydro-furan-2-carboxylic acid amide (120546-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / H₂O / 6 h / Heating

2: 29 percent / tetrahydrofuran; H₂O / 20 h / Ambient temperature; pH = 9.90

In tetrahydrofuran; water;

DOI:10.1021/ja00195a049

upstream raw materials:

(dl)-N_α-Benzoylhistidine methylamide

bicyclomycin

N-_α-Benzoylhistidine methyl ester